Pre-Confernce Short Courcses

プレカンファレンス - ショートコース

(SC1) タンパク質のフォールディング、リフォールディング、凝集 *
Protein Folding, Re-Folding and Aggregation

2008年4月27日(日) 2:00-5:00pm

インストラクター:
Theodore W. Randolph, Ph.D., Gillespie Professor, Center for Pharmaceutical Biotechnology Co-Director, University of Colorado (invited)
Carlos N. Pace, Ph.D., Texas A and M University

タンパク質のフォールディング

Thermodynamic forces that fold proteins (hydrogen bonds
vs. hydrophobic effects)
Kinetics of protein folding
Analytical methods to monitor protein folding

タンパク質の凝集

Colloidal and thermodynamic protein stability
Basic formulation strategies
Analytical methods for monitoring protein aggregation

タンパク質のリフォールディング

Pressure and chaotrope-based refolding methods
Designing screening studies to develop refolding conditions

(SC2) 抗体の前臨床段階の開発 *
Preclinical Development Antibodies

2008年4月28日(月) 9:00am - 12:00pm

インストラクター:
Mohammad Tabrizi, Ph.D., Director, MedImmune
Scott Klalamp, Ph.D., Principle Scientist, MedImmune
Gadi Bornstein, Ph.D., Principle Scientist, AstraZeneca R&D

Affinity Determination: Why Does It Matter, How Can It Impact Your Clinical Dose Selection?
How Do We Measure Affinity and the Challenges
Pharmacokinetics and Pharmacodynamics of Antibodies
Preclinical Development of Antibodies

(SC3) ファージディスプレイ及び酵母ディスプレイによる新規化合物のライブラリスクリーニング *
Phage and Yeast Display Library Screening for the Novice

2008年4月27日(日) 2:00-5:00pm

プレゼンター:
Jamie Kathleen Scott, M.D., Ph.D., Simon Fraser University
Andrew M. Bradbury, M.B. B.S., Ph.D., Los Alamos National Laboratory
James D. Marks, M.D., Ph.D., University of California, San Francisco

This workshop is meant to bring the novice up to speed on the display technologies covered by the main conference. The workshop will provide an overview of:

Phage display and construction of phage-displayed peptide, scFv and Fab libraries
Yeast display and construction of yeast-displayed scFv and Fab libraries
Screening technologies that are compatible with phage- vs. yeast-display libraries

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PROBLEM-SOLVING BREAK-OUT SESSIONS

Break-out Sessions are one hour group discussions focused on a particular topic. This is a moderated discussion with brainstorming and interactive problem solving amongst scientists from diverse areas who share a common interest in the discussion topic.

Program Links: