第14回 HTS(ハイスループットスクリーニング)のための生化学ベースアッセイ
分析の分量、効率性、情報制度の向上 : カタログダウンロード(英語版PDF)
5月13日(火) 〜 14日(水)
Title to Be Announced
Adam Hill, Ph.D., Director, Assay Development & HTS, Novartis
機能性酵素アッセイ
Discovery of Protease Inhibitor Probes by Target Class Profiling
Andrew Napper, Ph.D., Director, High-Throughput Screening, Penn Center for Molecular Discovery, University of Pennsylvania
Optimization of Enzymatic Assays for HTS: Sampling the Biochemical Space using a Parallel, Streamlined Approach
Daniele Carettoni, Ph.D., Head, Biochemistry, Axxam SpA
Title to Be Announced
Marshall Michener, Ph.D., Research Fellow, Inflammation Research, Pfizer Inc. (tentative)
Beyond Kinases: Interrogating the Purinome
Bob Lowery, Ph.D., President, CEO, Corporate, BellBrook Labs
結合分析
Drug Discovery in Academia: Two Examples of Novel Approaches to Biochemical Assays
Marcie Glicksman, Ph.D., Senior Director, Leads Discovery, Laboratory for Drug Discovery in Neurodegeneration, Brigham and Women’s Hospital
High-Throughput Screening for Inhibitors of p27Kip1 Proteolysis
Xuedong Liu, Ph.D., Associate Professor, Chemistry and Biochemistry, University of Colorado-Boulder
構造ベースアッセイ
An Example of the Fragonomics Paradigm
Anthony Macherone, Ph.D., Senior Director, Analytical & Bioanalytical Services, ASDI Group of Companies
推奨ショートコース *
5月13日(火)午後 (DC1) ディナーコース: 生化学ベーススクリーニングへ向けてのツールとアッセイの開発
Tutor: Daniele Carettoni, Ph.D., Head, Biochemistry, Axxam SpA Xuedong Liu, Ph.D., Associate Professor, Department of Chemistry and Biochemistry, University of Colorado-Boulder Functional Enzymatic Assays Structure-based Drug Design Binding Assays Topics to be addressed for each: The value of the expression host for recombinant protein expression Protein engineering: truncations, ancillary domains, tags, etc. Quality criteria for assay configuration aìnd screening Assays and type of inhibitors (active-site, allosteric, exosite, etc.) Types of assays used (surrogate substrates, enzymatic cascades, reactive probes, etc.) What is the readout? Benefits and limitations of each assay What is the degree of throughput? Homogeneous (addition-only steps) assays How can assay and equipment be adapted for target when more complex assays are needed?* こちらのコースへの出席に際しては別途お申し込みが必要となります。
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