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【英文市場調査報告書】

プロテオミクス: 最新解析技術、新薬開発と主要企業動向

Proteomics: Analysis of Selected Emerging Technologies

商品コード : 6524
出版日: 2001/01
発行 : Insight Pharma Reports (Formerly CHI Advances Reports)

※この商品は英文にてご提供いたします。

More than a dozen companies, including Amgen, Biosource Proteomics, Glaxo Wellcome, Hoffmann-La Roche, Incyte Genomics, Millennium Pharmaceuticals, and Oxford GlycoSciences, are using proteomics-the study of protein expression and function-to advance drug or diagnostic discovery and development. Preliminary results suggest that this new field will quickly lead to better pharmaceuticals in certain therapeutic areas, but with hundreds of tools to choose from and dozens of emerging applications, picking the right approach is critical. This report facilitates such decision making. It forecasts how proteomics will most successfully be used, in which therapeutic areas it will have its first impact, and how its various tools and approaches will evolve.

Proteomic technologies and applications of more than 50 companies are discussed, and detailed profiles, with contact information, are provided for 23 companies.

Written in language targeting business professionals, this report:

--Describes proteomics and how it is being used
--Evaluates current and emerging tools and approaches
--Assesses industry leaders and their strategies
--Examines prospects for various therapeutic and other applications

LIST OF TABLES

I. INTRODUCTION: Why Proteomics?

II. SCIENTIFIC BACKGROUND: The Challenge of Greater Complexity

A. Comparing Proteomics with Genomics

I. Similarities
ii. Differences

B. Using Proteomics and Genomics in a Complementary Fashion

III. THE CURRENT AND EMERGING TECHNOLOGIES: The Search for High Throughput

A. The First Level of Analysis: Protein Separation, Identification, and Characterization

I. Sample Preparation
ii. 2-D Gel Electrophoresis

a. The Standard Approach
b. New Developments
c. Overview

iii. Staining
iv. Image Analysis
v. Mass Spectrometry

a. The Main Technologies
b. Chromatography and Capillary Electrophoresis
c. Protein Identification Software
d. Overview

vi. Protein Chips
vii. Databases
viii. Bioinformatics

B. The Next Level of Analysis: Tools and Approaches for Protein Function Studies

I. Quantification
ii. High-Throughput Expression
iii. Protein-Protein Interactions
iv. Protein Function
v. What's Next?

a. Holistic Approaches
b. Advanced Molecular Modeling (In Silico Biology)

IV. BUSINESS AND STRATEGIC CONSIDERATIONS: The Leaders Are Far Ahead

A. Industry Leaders
B. Selected Tool and Service Providers
C. Bench-Top Platform Technology Providers

V. APPLICATIONS: Early Signs of Valuable Potential

A. Basic Research
B. Diagnostics and Prognostic Indicators
C. Drug Discovery and Development

I. Target Identification and Validation
ii. Pathway Elucidation
iii. Mode of Action
iv. Toxicology
v. Surrogate Markers of Drug Response
vi. Drug Resistance

D. Pathogen Studies
E. Agriculture and Other Areas

VI. OUTLOOK: New Tools and a Context for Managing Data

A. Key Remaining Issues

I. Is 2-D Gel Electrophoresis Replaceable?
ii. Access to Genetic Sequence Information
iii. Plain Skepticism

B. The Future of Proteomics
C. Commentaries from Editorial Board Members

Appendix A: Table of Companies with Proteomics-Related Activities
Appendix B: Company Profiles

※この商品は英文にてご提供いたします。

【英文市場調査報告書】
プロテオミクス: 最新解析技術、新薬開発と主要企業動向
Proteomics: Analysis of Selected Emerging Technologies
出版日: 2001/01


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商品コード : 6524

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