冠状動脈性心臓病と予防策

Overview

Introduction

According to the American Heart Association, coronary heart disease (CHD) caused one out of every five deaths in the US in 2002. However, the majority of CHD is preventable. Screening, lifestyle changes and drug therapy can reduce an individuals risk of CHD. This is particularly important where there is a clustering of risk factors in the same individual as seen in metabolic syndrome patients

Scope

• Understand the definition of atherosclerosis, its epidemiology, mortality statistics and the burden on healthcare spending
• Understand the risk factors which can be changed or treated to reduce the risk of atherosclerotic disease
• Learn about risk factor screening, global risk estimation and risk intervention measures including therapeutic lifestyle changes and drug therapy
• Appreciate the possibility of multiple risk factors being present in one individual as metabolic syndrome and the link to coronary heart disease

Report Highlights

Cardiovascular disease is the leading cause of mortality in the US and Europe. More than one in five deaths are from coronary heart disease (CHD). Moreover the cost of CHD is huge. The American Heart Association, estimates the cost will be $142 billion in 2005 and the British Heart Foundation estimates it costs the UK almost $14 billion per year

The majority of heart disease is preventable through education and identification of risk factors. These include hypertension, hypercholesterolemia, being overweight/obese, diabetes mellitus, smoking and physical inactivity. Guidelines promote a healthy diet, weight loss and physical activity, although drug therapy is recommended where insufficient

Metabolic syndrome is characterized by a cluster of risk factors in one individual. Central obesity and insulin resistance are considered important causative factors. This combination leads to a high risk of type 2 diabetes and cardiovascular disease with an accepted increase in risk of between 1.5 and two times

Reasons to Purchase

• Acquire data on the epidemiology of coronary heart disease to enable sizing of the market opportunity
• Understand how to target your product portfolio to the risk factors associated with coronary heart disease
• Understand the potential market in metabolic syndrome patients of targeting multiple risk factors in the same individual

ABOUT DATAMONITOR HEALTHCARE

• About the Cardiovascular pharmaceutical analysis team

EXECUTIVE SUMMARY

• Introduction
• Scope and coverage of the Brief
• Key findings

ATHEROSCLEROSIS OVERVIEW

• Disease definition
• Epidemiology
• Burden of atherosclerosis and coronary heart disease
• Mortality
• Cost

PREVENTION OF ATHEROSCLEROSIS

• Atherosclerotic risk factors
• Hypertension
• Hypercholesterolemia
• Overweight and obesity
• Diabetes
• Smoking
• AHA recommendations for the prevention of coronary heart disease
• Risk factor screening
• Global risk estimation
• Risk intervention
• Blood pressure control
• Blood lipid management
• Weight management
• Dietary intake
• Physical activity
• Smoking
• Aspirin
• Diabetes mellitus
• Therapeutic lifestyle changes
• Drug therapy
• Antihypertensives
• Statins
• Obesity drugs
• Antidiabetics
• Metabolic syndrome
• Metabolic syndrome definition
• Clinical criteria for diagnosis
• Metabolic syndrome and coronary heart disease

APPENDIX

• Bibliography
• Research methodology
• Disclaimer
• List of Tables
• Table 1: Epidemiology of cardiovascular disease, coronary heart disease and stroke in the US in 2002
• Table 2: Disability and mortality burdens of heart disease and stroke in the seven major markets in 2002
• Table 3: ATP III diagnostic criteria for metabolic syndrome
• Table 4: WHO working criteria for metabolic syndrome
• Table 5: IDF diagnostic criteria for metabolic syndrome