創薬および開発におけるケモゲノミクス（化学ゲノミクス）の商用利用

Summary

The time, cost, and complexity of the process of drug discovery can be drastically reduced through the application of chemical genomics and chemogenomics. The understanding and identification of the roles of chemistry and biology early in the development process will lessen not only the time of pre-clinical development, but also the risk of late clinical development failure. To achieve this acceleration of the processes, chemical genomics/chemogenomis integrates the latest developments in tools and technologies from a variety of disciplines; including combinatorial chemistry, informatics, synthetic chemistry, cell-based assays, microarrays, genomics, bioinformatics, toxicogenomics, and proteomics.

Scope

D&MD's Chemical Genomics Report provides an in-depth analysis of the promising market for chemical genomics and chemogenomics. The Report thoroughly examines chemical genomics and chemogenomics, their potential applications in the development of therapeutics for human diseases, and recent technology advancements. In addition, the intellectual property landscape is summarized, companies invested in chemical genomics and chemogenomics are profiled, and key industry players are interviewed.

Market Opportunities

• Utilize chemical genomics/chemogenomics to significantly reduce the time and cost of the drug discovery cycle.
• Employ chemical genomics/chemogenomics early in the drug development process in order to reduce the time, cost, and attrition associated with it.
• Integrate multiple discovery tools and technologies for chemical genomics in order to lessen the risks, costs, and time coupled with drug discovery and development.

Key Reasons to Buy

• Get a clear definition of chemical genomics and chemogenomics via an in-depth review of their current usage and applications adopted by several companies.
• Understand the current intellectual property landscape from a detailed summary of chemical genomics/chemogenomics patents.
• Gain reliable and thought-provoking insights into the chemical genomics/chemogenomics forecast through interviews with industry experts.
• Look inside companies working within the chemical genomics and chemogenomics markets, including their product pipelines, partnerships & alliances, business strategies, technologies, and more.

Table of Contents

Chapter 1: Executive Summary

Chapter 2: The Preface to Chemical Genomics and Chemogenomics

• The Traditional Drug Discovery and Development Process
  • Drug Discovery and Development: A Complex Process
  • Drug Discovery and Development: A Lengthy Process
  • Drug Discovery and Development: An Expensive Process
• Drug Discovery and Development: Bottlenecks
  • Discovery/Preclinical Bottleneck
  • Clinical/Drug Development Bottlenecks
• The Role of Chemistry

Chapter 3: Defining Chemical Genomics and Chemogenomics

• Context Leading to Chemical Genomics and Chemogenomics
• Defining Chemical Genomics.
  • Selected Definitions of Chemical Genomics
  • Classical Genetics to Chemical Genomics
  • Forward Genetics
  • Reverse Genetics
• Chemical Genomics and Chemogenomics Technologies
  • Company Technologies
  • Acadia Pharmaceuticals
  • Amphora Discovery Corp.
  • Current target classes under investigation by Amphora include:
  • Chemical Genomics Application:
  • Avalon Pharmaceuticals
  • Chemical Genomics Application:
  • Astex
  • Chemical Genomics Application:
  • ChemGenex Therapeutics
  • Chemical Genomics Application:
  • Graffinity Pharmaceuticals
  • Chemical Genomics Application:
  • Iconix Pharmaceuticals
  • Chemical Genomics Application:
  • Infinity Pharmaceuticals, Inc.
  • Chemical Genomics Application:
  • Morphochem
  • Chemical Genomics Application:
  • NeoGenesis
  • Chemical Genomics Application:
  • Vertex Pharmaceuticals
  • Chemical Genomics Application:
  • Definitions Revisited

Chapter 4: Role of Chemistry in Chemical Genomics

• Use of Small Molecules to Explore Biology
• Examples of Utilizing Chemical Genomic and Chemogenomic Approaches
  • Utilizing Yeast Deletion Strains in Chemical Genomics
  • Tools for Successful Chemical Genomics and Chemogenomics
  • Applying Combinatorial and Synthesis Chemistry in Chemical Genomics
  • Probing Biology with Chemistry
  • Calcium-calcineurin-NFAT signaling pathway
  • Small-molecule Dimerizers
  • TOR and the Nutrient Response-signaling Network
  • HDACs and Chromatin
  • Access to Chemical Diversity
  • Access to Chemical Genomics Data -The ChemBank Connection
• Applying Chemical Genomics in Anticancer Drug Discovery and Development
• Summary and Conclusions

Chapter 5: Opinions from Industry Experts

• Reinhard Ebner, Ph.D.
• Bill Heilman, PhD
• Alan Engelberg
• Martin F. Haslanger, Ph.D.,
• Guri Giaever
• Andrew W. Stern, Ph.D.

Chapter 6: Company Profiles

• ACADIA Pharmaceuticals Inc.
• Amphora
• Astex Technology
• Avalon Pharmaceutical
  • Technology, Research and Development
• ComGenex International
• Graffinity.
• Iconix Pharmaceuticals.
• Infinity Pharmaceuticals
• NeoGenesis

Chapter 7: Recommended Reading

TABLE OF EXHIBITS

• Exhibit 1.1 Publications in the Chemical Genomics Field
• Exhibit 1.2 Drug Discovery and Development: Comparison of Traditional with Chemical Genomics Approach
• Exhibit 2.1 Drug Discovery and Development: Time and Money
• Exhibit 2.2 Drug Discovery and Development: Bottlenecks
• Exhibit 2.3 Schematic Segmentation of Drug Targets Depicted from Human Genome Sequencing
• Exhibit 2.4 From Discovery to Fruition. Comparing Sequence, Gene Discovery, Targets, and Chemistry
• Exhibit 2.5 How Chemistry and Screening Fits into the Big Picture of Discovery and Development
• Exhibit 3.1 Defining Chemical Genomics.
• Exhibit 3.2 Comparing Drug Discovery and Development between Pharmaceutical and Biotechnology Companies
• Exhibit 3.3 Schematic Defining different Aspects of Chemical Genomics
• Exhibit 3.4 Definitions Associated with Chemical/chemo-genomics Paradigm
• Exhibit 3.5 Schematic Showing Drug Discovery Linear Process and Chemical Genomics Based Parallel Fashion
• Exhibit 3.6 Defining and Comparing Forward Genetics, Reverse Genetics, Forward Chemical Genetics and Reverse Chemical Genetics
• Exhibit 3.7 Acadias Chemical Genomics Approach
• Exhibit 3.8 Avalon Pharmaceuticals Chemical Genomics Approach.
• Exhibit 3.9 Iconix Pharmaceuticals Chemogenomics Approach
• Exhibit 3.10 Schematic of Morphochems Chemical Genomics Approach.
• Exhibit 3.11 Schematic of Neogenesis Approach for Drug Target Based Small Molecule Identification
• Exhibit 3.12 Schematic of Comparing Traditional Approach with Chemical Genomics Approach
• Exhibit 4.1 Schematic of Drug Discovery Approach for Anti-cancer Drug Discovery.
• Exhibit 4.2 Schematic of the Comparison of Conventional Small Molecule Drug Discovery Approach with Chemical Genomics Approach
• Exhibit 4.3 Applications of Chemical Genomics
• Exhibit 6.1. Schematic of Acadias Drug Discovery Approach
• Exhibit 6.2 Schematic of Avalon Pharmaceuticals Therapeutics Anti-cancer Drugs