バイオプロセス業界動向

Abstract

D&MD's The Bioprocessing Industry: Increasing Capacity, Production, and Efficiency, 2nd Edition marketing analysis report presents a thorough and organized analysis of this critical industry and its major components. This report covers the most important issues in bioprocessing including the threat of a significant shortage in manufacturing capacity, consolidation in key sectors of the industry and the next drug discovery trends fueling expansion. In addition, more than 50 companies from various elements of the bioprocessing industry are profiled in depth.

Table of Contents

Chapter 1: Executive Summary

Chapter 2: Introduction

• The Bioprocessing Industry
• Scope and Objectives of the Bioprocessing Report
  • Report Scope
  • Report Objectives

Chapter 3: Types of Biologicals and Their Applications

• Drugs
  • Antibiotics
  • Hormones
  • Cytokines (Cell Growth Factors)
  • Enzymes
  • Vaccines
  • Blood Fractions
  • Monoclonal Antibodies
  • Diagnostics

Chapter 4: Regulatory Requirements for Bioprocessing

• Facilities
• Equipment
• Processes

Chapter 5: Bioprocessing Science and Technologies

• Mass Cell Culture Techniques
  • Cells for Culture
  • Culture Media
  • Culture Equipment
    • Bacterial Fermentors
    • Animal Cell Suspension Culture
    • Anchorage-dependent Cell Culture
    • Microcarrier Culture
    • Hollow-Fiber Devices
    • Transgenic Animals and Plants
• Separation Technology
  • Centrifugation
  • Cell Disruption
  • Filtration
• Purification Technology
  • Chromatography
    • Ion-Exchange (IEC)
    • Hydrophobic Interaction (HIC)
    • Biospecific Affinity
    • Gel Filtration (GF)
    • Reversed Phase Chromatography (RPC)
    • Perfusion (PC)
    • Typical Protocols
      • Purification of Mouse MAb by AC or HIC
      • Other Uses of AC
      • Expanded Bed and Radial Chromatography
  • Filtration
    • Submicron Filtration
    • Ultrafiltration
  • Ultracentrifugation
  • Other Technology
    • Magnetic Beads
    • Electrophoresis
    • Virus Inactivation
• Processing the Final Product
  • Formulation, Stabilization and Delivery Systems
  • Lyophilization
• Analytical Technology
  • Chemical Techniques
  • Physical Techniques
  • Biological Techniques
• Basic Support Utilities
  • Water Purification
  • Sterilization
  • Contamination Control
• Disposables in Bioprocessing
• Disposable Technology and Contract Manufacturing (CMOs)
• Drivers for Single-use Disposable Systems
  • Cost Implications
• Disadvantages of Disposable Systems
  • Leachables and Extractables
  • Elimination of Waste in the Biodisposable Context
• Disposable Bioreactors
  • Applications for Disposable Bioreactors
• Disposable Downstream Processing
  • Faster Processing
  • Cleaning Ease
  • Disposable Filters

Chapter 6: Contract Services in Bioprocessing

• Contract Manufacturers
• References

Chapter 7: Future Directions of Bioprocessing

• Mass Cell Culture
  • Expression Systems
  • Bioreactor Design
  • Media Improvements
  • Transgenics
• Separation
• Purification
• Integrated Processing
• Final Formulation, Stabilization and Lyophilization
• Analysis and Automation

Chapter 8: Company Profiles

• Abgenix
• Becton Dickinson
• Boehringer Ingelheim
• CSL
• DSM Anti-Infectives
• Dyax
• GE Healtcare
• GTC Biotherapeutics
• Invitrogen
• Large Scale Biology
• Neose Technologies
• PPL Therapeutics
• ProMetic Life Sciences
• Tosoh Corporation
• West Pharmaceutical Services