D&MD' s Commercial Opportunities in Enzyme Technologies, 3rd Edition examines
the many current opportunities for enzymes as well as areas targeted for
future growth. Specific attention is paid to the growing and various uses of
enzymes over several industries from industrial uses to therapeutic targets.
In addition, this Report profiles companies designing and producing enzymes,
detailing their technologies and product pipelines
Table of Contents
CHAPTER 1: EXECUTIVE SUMMARY
CHAPTER 2: INTRODUCTION
CHAPTER 3: FOUNDATIONS
General Principles
Background
Enzymes as Catalysts
Michaelis-Menten Kinetics
Inhibition
Regulatory Enzymes
Cofactors and Prosthetic Groups
Membrane Enzymes
Multiplicity and Isoenzymes
Enzymes in Metabolism
Formal Classification Groups for Enzymes
The Six EC Nomenclature Classes
Proteases
Saccharases
Lipases
Other Enzymes of Industrial Importance
Enzyme Assays
Colorimetric Assays
Fluorimetric Assays
Electrochemical Assays
Other Types of Assays
CHAPTER 4: ENZYME ENGINEERING
Source Organisms
Extremophiles
Thermophiles
Psychrophiles
Halophiles
Acidophiles
Alkalophiles
Piezophiles
Mesophilic Terrestrial Bacteria
Eukaryotes
Strategies for Developing Diversity Libraries
Other Sources of Diversity
Abzymes
Engineering Goals
Engineering Enzymes to Survive in Industry Environments
Protein Engineering Lessons Learned from Thermophiles
Improving Enzyme Activity at Low Temperature
Increasing Tolerance to Extremes in pH
Incompatibility between Thermal Stabilization and Low Temperature
Activity
Selecting for Multiple Parameters
Compatible Solutes
Engineering Methods
Modeling and Rational Design
Evolution
Screening
Format and Purification
CHAPTER 5: ENZYMES AS COMMERCIAL PRODUCTS
Market Demand for Enzymes
Detergent Additives
Food Additives and Food Processing
Corn Syrup
Alcohol and Beverages
Rennet and Rennet Substitutes
Enzymes for Feed Supplementation
Phytase
Xylanase
Other Feed Additive Enzymes
Thermostabilization of Feed Supplement Enzymes
Industrial Production of Enzymes for Feed Additives
Major Competitors with Enzyme Supplementation for Feed
Pharmaceuticals
FDA-Approved Enzyme Drugs
Research and Development Products
Signaling (Probe) Enzymes
Alkaline Phosphatase and Horseradish Peroxidase
Luciferase
Expression Tags
Proteases
Lysozyme
Nucleases
Taq and other Thermostable DNA Polymerases
Restriction Endonucleases
DNAse and RNAse
Reverse Transcriptase
Other Specialty Enzymes
Clinical Assays
Forensic PCR
PCR Basics
Human Variations
Clinical PCR
ELISA
CHAPTER 6: ENZYMES AS THERAPY TARGETS
Enzyme Target Families
CHAPTER 7: POTENTIAL GROWTH AREAS FOR ENZYMES
Pharmaceutical Processing
Chiral Resolutio ns
Chiral Examples
Nonchiral Examples
Solid Phase Enzyme Chemistry
Biocatalysis Formats
Solid Phase Enzyme Chemistry Example
Specialty Chemical Applications
Biopulping
Paper and Pulp
Fermentation Feedstock
Waste Remediation
Explosives
Organophosphates in Pesticide Residues and Nerve Gas
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