Abstract
In This Issue...
Apoptosis, the major and best-studied pathway of programmed cell death, plays
an important role in embryonic development, the immune system, and protection
against mutations and cancer. As such, it has become an intriguing focus of
investigation among pharmaceutical companies seeking to treat illnesses
ranging from cancer to cirrhosis. In this report, we explain the apoptotic
process, discuss several proteins within the apoptotic pathways that may
represent potential targets for drug development, describe apoptosis
modulators and inhibitors in development, and analyze the challenges
associated with developing agents that target this pathway, especially those
associated with caspase inhibitors.
Table of Contents
Introduction
An Overview of Apoptosis
- Characteristics of Apoptosis
- Detecting Apoptosis
- Role of Apoptosis in Human Development
- Role of Apoptosis in Disease
- The Apoptotic Pathways
Apoptosis Activators in Development for Cancer
- Bcl-2 Inhibitors
- IAP Inhibitors
- TRAIL Receptor Agonists
- Other Intrinsic Pathway Drug Discovery Methods
Caspase Inhibitors as Antiapoptotic Agents
- Challenges to Caspase Inhibitor Development
- IDN-6556
Outlook
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