薬剤標的の特定とバリデーションのための戦略

Abstract

In This Issue...

Target-based drug discovery has become the prevailing paradigm used by pharmaceutical and biotechnology companies. This approach is appealing because it holds the promise of identifying more-efficacious compounds with fewer undesirable side effects. Companies have therefore invested significant resources in acquiring and developing technologies for identifying and validating new drug targets. This report explores both state-of-the-art and emerging target identification and validation technologies and methods. We consider the limitations of these technologies and their impact on drug discovery, examine relevant business models, and profile selected companies with novel target identification and validation technologies.

Table of Contents

Introduction

Drug Target Identification

Target Validation Technologies

Impact of New Targets on Drug Discovery

Corporate Highlights

Outlook