Abstract
Introduction
Stem cell therapy development is challenged by controversy, intellectual
property issues, and a high failure rate. Despite these challenges, stem cell
therapy presents some of the most promising options for hard-to-treat and
highly degenerative neurological diseases.
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Stem cell therapy holds vast potential for treating degeneration or injury in
areas of the body that are incapable of autonomous healing, such as the
central nervous system (CNS). How can stem cells boost healing in the CNS?
What are the limitations of these therapies in the CNS? What scientifi c and
regulatory roadblocks exist for developing stem cell therapies for the
CNS? Several manufacturers are investigating stem cell therapies to treat
neurological disease. What are the different approaches for developing
these therapies? What value do different stem cell therapies offer, and what
challenges do they face? How might these agents impact the different disease
markets?
Stem cell therapies may represent the fi rst true disease-modifying therapies
for multiple neurological diseases, but their success will depend on many
factors, including ethics, clinical trial design, and safety concerns. How
are ethics affecting stem cell design? What can we expect from future stem
cell clinical trials? Which stem cell therapies are likely to offer the best
safety profi les?
Scope
- Stem cell introduction: stages of stem cell differentiation,
comparison of stem cell types, history of stem cell development.
- Value of stem cells for neurological diseases: benefi ts and
limitations of stem cells and their therapeutic value for multiple
neurological indications, including Alzheimer' s disease and Parkinson' s
disease.
- Emerging stem cell therapies for neurological uses: discussion of
multiple companies' initiatives into developing neurological stem cell
therapies.
- Outlook: hurdles for stem cell therapy development, discussion of
which stem cell therapies are more likely to succeed.
Mentioned in This Spectrum Report
Companies
- Advanced Cell Technology
- Athersys
- Berlex
- Boehringer Ingelheim
- BrainStorm Cell Therapeutics
- Ferrer Internacional
- Genentech
- Geron
- Kyowa Hakko
- Mitsubishi Pharma
- ReNeuron Group
- Saneron CCel
- Sanofi -Aventis
- Schering
- Stem Cell Therapeutics
- StemCells
- Titan Pharmaceuticals
Table of Contents
- Executive Summary
- Strategic Considerations
- Stakeholder Implications
- Introduction
- Overview of Stem Cell Development
- History of Stem Cell Research
- Potential of Stem Cell Therapies in Neurological Disease
- Stroke
- Alzheimer' s Disease
- Parkinson' s Disease
- Spinal Cord Injury
- Multiple Sclerosis
- Huntington' s Disease
- Amyotrophic Lateral Sclerosis
- Lysosomal Storage Diseases
- Leading Companies in Stem Cell Therapeutics for Neurological Disease
- StemCells
- Geron
- ReNeuron Group
- Stem Cell Therapeutics
- Athersys
- BrainStorm Cell Therapeutics
- Advanced Cell Technology
- Saneron CCel
- Outlook
Tables
- 1. Types of Stem Cells
- 2. Neurological Disorders That May Benefit from Stem Cell Therapy
- 3. Key Research Studies on Stem Cells in Stroke
- 4. Key Research Studies on Stem Cells in Alzheimer' s Disease
- 5. Key Research Studies on Stem Cells in Parkinson' s Disease
- 6. Key Research Studies on Stem Cells in Spinal Cord Injury
- 7. Companies Developing Stem Cell Therapies
Figures
- 1. Stem Cell Differentiation
- 2. Important Events in the History of Stem Cell Research
- 3. Government Policies Regarding Stem Cell Research
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