神経系疾患治療のためのスタチンおよびPPARガンマ作動薬

Abstract

Introduction:

The repositioning of agents to treat neurodegenerative disorders represents a signifi cant opportunity for companies that have products in highly competitive markets. Although the value of neurodegenerative markets is small by comparison, the signifi cant unmet need and the severity of these diseases mean that an emerging agent that can offer even a modest improvement over available therapies is likely to establish a share in the market.

Get the Answers You Need to Shape Your Strategy:

Both Alzheimer' s disease (AD) and multiple sclerosis (MS) have relatively small patient populations. Nevertheless, what factors make these two markets especially appealing to drug developers interested in repositioning their drugs? Similarities between the pathogenesis of AD and the pathogenesis of cardiovascular disease suggest that statins may have some effect on AD. What are the similarities, and what have been the results of clinical trials thus far?

Likewise, there are a number of connections between insulin metabolism and AD. Diabetes is, in fact, a risk factor for AD. What are the connections, and what have been the results of clinical trials investigating the effect of PPAR-gamma agonists on AD? Pfi zer and GlaxoSmithKline are two major drug developers actively seeking to reposition their products into the neurological markets (Pfi zer with its statin Lipitor [atorvastatin] and GlaxoSmithKline with its PPAR-gamma agonist Avandia [rosiglitazone]). What are the factors behind these companies' decisions to investigate new markets?

Scope:

• The AD therapy market: key statistics.
• The MS therapy market: key statistics.
• Use of statins in treating AD: similarities in disease pathophysiology and clinical support for statin use.
• Use of statins in treating MS: similarities in disease pathophysiology and clinical support for statin use.
• Use of PPAR-gamma agonists in treating AD: similarities in disease pathophysiology and clinical support for statin use.

Mentioned in This Spectrum Report:

Companies/Institutes

• Bayhill Therapeutics
• Biogen Idec
• Eisai
• Eli Lilly
• GlaxoSmithKline
• Johnson & Johnson
• Merck
• National Institute on Aging
• Pfi zer
• Serono
• Sun Research Institute
• Takeda
• Teva Pharmaceuticals

Drugs

• Actos (pioglitazone)
• Aricept (donepezil)
• Avandia (rosiglitazone)
• Avonex (interferon beta-1a)
• BHT-3009
• Copaxone (glatiramer acetate)
• Lipitor (atorvastatin)
• Rebif (interferon beta-1a)
• Topamax (topiramate)
• Zocor (simvastatin)

Table of Contents

• Executive Summary
• Strategic Considerations
• Stakeholder Implications
• Introduction
• Opportunity in Neurological Disease Markets
• The Alzheimer' s Disease Market
• The Multiple Sclerosis Market
• The Use of Statins in Treating Alzheimer' s Disease
• Pathophysiology of Alzheimer' s Disease
• Statins' Potential Effect on Alzheimer' s Disease
• Clinical Support for Statin Use in Treating Alzheimer' s Disease
• Commercial Interest in Developing Statins for Alzheimer' s Disease
• The Use of Statins in Treating Multiple Sclerosis
• Pathophysiology of Multiple Sclerosis
• Statins' Potential Effect on Multiple Sclerosis
• Clinical Support for Statin Use in Multiple Sclerosis
• Commercial Interest in the Development of Statins for Multiple Sclerosis
• The Use of PPAR-Gamma Agonists in the Treatment of Alzheimer' s Disease
• Potential Effect on Alzheimer' s Disease
• Clinical Support for PPAR-Gamma Agonists in Alzheimer' s Disease
• Commercial Interest in Developing PPAR-Gamma Agonists for Alzheimer' s Disease
• Outlook

Tables

• 1. Leading Agents to Treat Alzheimer' s Disease in the Major Pharmaceutical Markets, 2005
• 2. Leading Agents to Treat Multiple Sclerosis in the Major Pharmaceutical Markets, 2005
• 3. Pfizer' s Lipitor: A Fact Sheet
• 4. Clinical Trials Investigating the Use of Statins to Treat Multiple Sclerosis
• 5. Pfizer' s Top-Selling Products, 2005

Figures

• 1. Sales of Agents to Treat Alzheimer' s Disease, 2005-2010
• 2. Sales of Agents to Treat Multiple Sclerosis, 2005-2010