中枢神経系創薬：うつ病

Abstract

The market for antidepressive drugs is the largest segment of the CNS sector with global sales of US$16.2 billion in 2005. Find out more in this chapter of CNS Drug Discoveries.

The market for antidepressive drugs is the largest segment of the CNS sector with global sales of US$16.2 billion in 2005, and annual growth of 2% year on year. This is a saturated market where a number of generics have been launched and eroded the market share of leading brands. This chapter focuses on the ways in which companies have optimised the life-cycle of their products through new formulations, combination and new products in order to protect their franchises. It looks at the changing dynamics in the marketplace and evaluates how effective the launch of Cymbalta (Eli Lilly), and Wellbutrin XL (GSK), have been.

It is estimated that depression affects over 18.8 million US citizens and over 121 million people worldwide, with approximately 20% of the global population at risk of developing major depression at some point in their lives. Women are almost twice as likely to suffer from depression as men (9.5% versus 5.8%), but prevalence figures vary from country to country. Depression costs the US economy an estimated US$44 billion each year and the WHO predicts depression will become the leading cause of disability by the year 2020.

Global depression market

The global market for antidepressants is unevenly distributed. In 2005, the US antidepressant market accounted for 66% of the global market compared to 23% in Europe and 11% rest of world (largely Japan).

We believe the depression market is now saturated as numerous formulations, combinations and generics are available. In order for new products to capitalise on this market they will have to demonstrate improvements in the efficacy, speed of onset, safety/tolerability of drugs and a reduction in remission rates and relapse/recurrence.

Table of Contents

DEPRESSION

• EXECUTIVE SUMMARY
• THE FACTS
  • What is depression and why are we interested in it?
• PATIENT STATISTICS
  • Incidence, diagnosis rates and treatment; now and in the future
• PATIENT MODEL
  • Summary of patient population forecasts in seven major markets (2005A-2012E)
  • Model assumptions
• DRUG GROWTH DRIVERS
• DRUG GROWTH RISKS/DAMPENERS
• GLOBAL ANTIDEPRESSANT MARKET
  • Global CNS Market (US$68.7 billion)
• GLOBAL SALES SPLIT
  • Global sales by region (2005A)
  • US market
    • Antidepressant US drugs sales by (2005A)
  • European market
    • European Antidepressant sales by (2005A)
  • ROW/Japanese market
  • The Major Players Products in 2005 & 2006
    • Market share of Antidepressant players by sales (Dec 2005A)
  • The Major Players and Products in 2012
    • Market share of Antidepressant Players by sales (Dec 2012E)
• CURRENT TREATMENTS
  • Leading Brands
    • Comparison of leading antidepressant drugs
  • Patent Exposure of Current Products
    • Patent Exposure of Leading Antidepressant Brands
• ANALYSIS OF LEADING BRANDS
  • Selective Serotonin Reuptake Inhibitors (SSRIs)
    • Lexapro/Cipralex (Forest/Lundbeck)
    • Prozac (Eli Lilly)
    • Zoloft (Pfizer)
  • Serotonin and Noradrenaline Reuptake Inhibitors (SNRIs)
    • Cymbalta (Eli Lilly)
    • Effexor (Wyeth)
  • Noradrenaline and Dopamine Reuptake Inhibitors (NDRIs)
    • Wellbutrin (GlaxoSmithKline)
• GLOBAL SALES FORECASTS OF CURRENT TREATMENTS 2005 - 2012
  • Sales Forecasts of Current Leading Antidepressant Drugs
  • Model assumptions
• NEW DRUGS IN R&D
  • Drugs in Development to Treat Depression and Anxiety Related Disorders
• ANALYSIS OF PHASE III DRUGS
  • New Drugs in Phase III Development to Treat Depression and Anxiety
  • Phase III drugs
  • Other Phase III drugs of interest