欧州における ADME/Tox 技術市場

Research Overview

Increasing Clinical Failures of New Drugs Call for a More Effective Use of ADME/Tox Technologies

With absorption, distribution, metabolisation and excretion/toxicity (ADME/Tox) technologies becoming more advanced and reliable in terms of accuracy and predictiveness, an increase in their usage is expected during the initial development and screening phase of innovative drugs. Development and approval of new drugs commonly take between seven and ten years and cost anywhere between $400 million and $500 million. Indications that 90 per cent of the clinical candidates are likely to fail due to pharmacokinetics (ADME-related) problems, lack of efficacy and side effects make this a high risk business for drug companies. As a result, manufacturers are realising the importance of screening potential "hit compounds" for significant ADME and toxicity profiles earlier on in their development phase.

This Frost & Sullivan research service covers the European ADME/Tox technologies market. It examines the existing competitive structure and evaluates the business potential in major markets, taking into account market drivers and industry dynamics. The study also looks at emerging technologies and provides a Decision Support Database (DSD) to help make strategic decisions.

Technologies that Focus on Complete Solutions Have Larger Presence in the ADME/Tox Tools Market

As the number of target drugs increases, the expanding volume and complexity of data are highlighting the need for extensive use of informatics to manage data for analysis and interpretation. Biotechnology and pharmaceutical companies are opting for sophisticated software that can filter out compound leads that could develop into drugs, predict biological properties and incorporate improved ADME/Tox screening. Doing so early in the drug development stages helps reduce the cost and time spent on compound failures. This has also spurred the adoption of in-silico techniques, which are complex and accurate models for rationalising and predicting ADME properties, allowing for better prediction complex systems.

"The combination of robotics with instrumentation is important to achieve high screening rates and to reduce time-consuming/costly manual interventions," says the analyst of this research. "The testing market is moving towards higher-density, lower volume formats that bring real savings in reagent costs and conserve the supply of precious compounds." Although, there are few problems with any of the innovative technologies coming into the market, some companies will be slow to adapt to these changes for a number of reasons.

Need for More Powerful Prediction Tools Ensures Further Market Growth

In a growing market characterised by increasing competition, the key is to develop systems and solutions that allow scientists to keep up with the ever increasing output and efficiency. Data consolidation, information sharing and standardisation of technologies would encourage the market to function efficiently and competitively.Partnering between clinical organisations and informatics and tool companies will allow manufacturers to create solutions that best meet the needs of the researchers. The uncertainty surrounding in-silico technologies will require promotion through peer reviewed literature for better market penetration.

Amidst rapid technological progress, traditional technologies are not likely to be replaced completely. Instead, the integration of new applications is likely to increase their use and drive the lead evaluation and optimisation and pre-clinical evaluation market. "Despite the restraints, for the long term, computational technologies and predictive solutions will increase the scope for the industry and the number of drugs which progress from the research to the clinical stage," concludes the analyst.

1 STRATEGIC ANALYSIS OF THE ADME/TOX TECHNOLOGIES MARKET IN EUROPE

Overview

Overview

Research Scope and Methodology

Research Scope and Methodology

Introduction and Background

Introduction and Background

Key Definitions and Abbreviations

Exchange Rates

Background and Drug Discovery Processes

Successful Drug Candidates

Secondary Screening

Failure of Lead Candidates

ADME/Toxicity Testing

Role of ADME Studies for Drug Discovery

Global ADME/Tox Screening Market Revenue

Therapeutic Efficacy and Toxicity

Drug-like Properties for ADME/TOX Studies

ADME/Tox Profiles I-II

Market Dynamics

Market and Technology Trends I & II

Industry Challenges

Using ADME/Tox to Overcome Challenges

Market Drivers

Market Restraints

Market Status and Size

Total Market Forecasts

Assumptions

Key Market Engineering Measurements

EU ADME/TOX Market Revenue Forecasts

EU ADME/TOX Market Revenue Analysis

Segmentation of ADME/TOX Market

Segmentation Revenue Forecasts

Segmentation Revenue Analysis

Company Profiles

Strategic Analysis and Recommendations

Major Challenges and Strategies

Summary of Strategic Proposals

Quotes

Market Maturation Process

Strategic Anticipation

Potential Threats

Competitive Framework

Market Potential

Three Levels Of Strategies

Pricing Strategy

Meeting the Challenge

Frost & Sullivan Awards

Frost & Sullivan Awards

Product Innovation Award

Customer Service Innovation Award

Growth Strategy Leadership Award

Market Penetration Leadership Award

Industry Participants

Industry Participants

Decision Support Databases

Decision Support Databases

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