1,000ドル・ヒトゲノム：ライフサイエンス、ヘルスケア、ITにおける意味

This IDC study incorporates survey data and in-depth interviews from thought leaders in the fields of genomics, genetics, bioinformatics, and technology development. The panel consists of CEOs/presidents and chief scientific officers (CSOs) from life science technology companies, directors and lead scientists from pharmaceutical and biotechnology companies, executives and directors from information technology and bioinformatic companies, senior faculty from top-tier academic and research institutes, directors and scientists from large DNA sequencing facilities, plus partners of venture capital firms investing in life science companies.

This document combines the qualitative data gathered from interviews with the quantitative survey results to formulate insights and actions for IT hardware and software vendors, life science platform/equipment developers, pharmaceutical/biotechnology companies, and companies developing genomic-based technologies. Some of questions answered are:

• What advancements in life science and healthcare will occur as the cost of sequencing a human genome declines?
• What are the price points at which DNA sequencing will become part of drug discovery, clinical trials, and personalized medicine?
• Which markets will adopt DNA sequencing technologies at each declining price point?
• How long will it take to develop a faster and cheaper DNA sequencing technology, and what are the major technical issues?
• What are the bioinformatic issues for ultra-high-throughput DNA sequencing, and what components of the IT infrastructure will require new solutions?
• Who are the new companies developing DNA sequencing technologies, and how will the life science and DNA sequencing market react as the cost declines?

Faster and cheaper DNA sequencing technologies have the potential to revolutionize science and medicine. Zachary Zimmerman, Ph.D., of Life Science Insights, an IDC company states, "Several start-up companies are trying to develop new, disruptive DNA sequencing technologies. Many see the DNA sequencing market poised for dramatic growth as personalized medicine becomes a reality and as pharmaceutical companies attempt to reduce drug development costs and improve clinical trial successes by utilizing genomic data to segment the population into specific cohorts."

IDC Opinion

In This Study

Methodology

Executive Summary

Situation Overview

Introduction

What Is the Difference Between a Draft and a Finished Sequence?

How Much Did the Human Genome Project Cost?

How Much Does It Cost to Sequence a Human Genome Today?

Who Is Currently Performing Large-Scale DNA Sequencing Projects?

How Large Is the DNA Sequencing Market?

What Is the DNA Sequencing Market's Future Growth Potential?

What Are the Funding Opportunities for New DNA Sequencing Technologies?

What Are Some of the New Technological Approaches Being Developed for DNA Sequencing?

Intelligence

How Many Years Until the Cost of Sequencing a Human Genome Is in the Thousands of Dollars?

Figure: Human Genome Sequencing Cost-Reduction Time Line

How Long Until the Cost of Human Genome Sequencing Is Under $1 Million, Under $100,000, and Under $1,000?

Key Points: Time Line for the Declining Cost of Human Genome Sequencing

Figure: Years to Achieve $1 Million Human Genome

Figure: Years to Achieve $100,000 Human Genome

Figure: Years to Achieve $1,000 Human Genome

Which Technology Will Affect the Cost of Sequencing in 2 Years, 5 Years, and 10 Years?

Figure: Technological Advancements Influencing DNA Sequencing in the Next 2, 5, and 10 Years

Key Points: Impact of the New DNA Sequencing Technologies over Time

What Are the Roadblocks Preventing the Advancement of DNA Sequencing?

Table: Technological Issues Affecting DNA Sequencing Technologies

Key Points: Issues Affecting the Development of New DNA Sequencing Technologies

What Bioinformatic Developments Are Needed for High-Throughput DNA Sequencing?

Figure: Bioinformatic Developments Necessary for Ultra-High-Throughput DNA Sequencing

Which Components of the Information Technology Infrastructure Will Require New Solutions?

Figure: IT Infrastructure Components Requiring Advancement for Applications

Key Points: IT and Bioinformatic Developments Required for the $1,000 Human Genome

What Projects Could Be Performed if a Human Genome Costs $10 Million, $1 Million, $100,000, $10,000, or $1,000?

Table: Scientific/Medical Projects at Each Human Genome Price Point (% of Respondents)

Key Points: Life Science and Healthcare Opportunities at the Declining Price Points of Human Genome Sequencing

Which Markets Would Adopt a Technology Capable of Sequencing a Human Genome for $1 Million?

Which Markets Would Adopt a Technology Capable of Sequencing a Human Genome for $100,000?

Figure: Markets for $1 Million Human Genome DNA Sequencing Technology

Figure: Markets for $100,000 Human Genome DNA Sequencing Technology

Which Markets Would Adopt a Technology Capable of Sequencing a Human Genome for $1,000?

Figure: Markets for $1,000 Human Genome DNA Sequencing Technology

Key Points: New Market Opportunity Adoption as the Cost of Human Genome Sequencing Declines

At What Price Point Would a New Sequencing Technology Replace a Current Technology?

Figure: Price Point Required to Replace Current Sequencing Technology

At What Price Point Will a Scientist Who Is Not Sequencing Consider Genomic-Based Research?

Figure: Price Point Required for New Research Laboratory Adoption

At What Price Point Will Genome Sequencing Become a Part of Clinical Trials?

Figure: Price Point Required for Clinical Trial Adoption

At What Price Point Will Genome Sequencing Become Commonplace at a Doctor's Office?

Figure: Price Point Required for Healthcare Adoption

At What Price Point Will Genome Sequencing Replace Genotyping?

Figure: Price Point Required for Whole Human Genome Sequencing to Replace SNP Genotyping

What Factors Limit Genome Sequencing as a Clinical Tool?

Figure: Factors Affecting Adoption of Human Genome Sequencing in Clinical Trials

Key Points: New Market Adoption

Which Companies Will Impact Sequencing in 2 Years, 5 Years, and 10 Years?

Key Points: the Companies Developing Genomic Technologies

Table: DNA Sequencing Technology Companies Affecting Sequencing Costs in the Next 2, 5, and 10 Years (% of Responses)

Summary

Future Outlook

Table: Forecast Assumptions for the DNA Sequencing Market, 2004-2016

Insight

Insights for the $1 Million Human Genome

Insights for the $100,000 Human Genome

Insights for the $10,000 Human Genome

Insights for the $1,000 Human Genome

Figure: Worldwide Revenue Increase in DNA Sequencing from Technologies Reducing Human Genome Sequencing Cost

Table: Key Forecast Assumptions for the DNA Sequencing Market, 2004-2016

Essential Guidance

Action

Information Technology Vendors

Life Science Equipment Manufactures

Pharmaceutical Companies and Biotechnology Companies

Start-Up DNA Sequencing Research and Development Companies

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Synopsis