ワクチン：世界市場の分析、主要企業および主要動向の分析 - 2008年

Abstract

Few areas of pharmaceuticals have seen the fast-moving developments in the marketplace that the vaccine market has in 2007 and 2008. Since Kalorama Information last updated Kalorama Information' s The World Market for Vaccines in the first quarter of last year, new products and better than expected profits have transformed the vaccine marketplace. Approvals that have been granted for products such as RotaTeq, Pentacel, Adacel and Zostavax and FluMist are now impacting the market. The launch and execution of the first successful cancer vaccine product, Merck' s Gardasil, has had dramatic and surprising results. Other products also exceeded revenue expectations. The competitive dynamics have changed with merger activity, and many new products are on the way.

Kalorama vaccine market analyst Allison Sahoo' s exhaustive research and analysis of interviews with key decision makers in the market includes the following:

• Review of Products in the Market
• Current World Market Size for Pediatric and Adult Vaccines
• Segmented Revenues and Forecasts to 2013 by Category
• Over 45 Charts and Tables To Make Information Accessible
• Important Vaccines and Immunization Schedules and Statistics
• Discussion of Issues and Trends in the Vaccine Market
• Profiles of 15 Key Vaccine Companies
• Thorough Review of the Vaccine Pipeline and Possible Impact of New Products

Who are the main players in the vaccine market? What opportunities are available for pharmaceutical companies or investors from this market? What are the potential challenges vaccine competitors must deal with? What will be the impact of the first successful cancer product? What is the significance of at least one major acquisition to affect this industry? These questions and more are tackled in this report.

Current revenues and revenue forecasts to 2013 are included for the following pediatric vaccine categories:

• DTaP & DTP Vaccines
• Hep Vaccines
• HiB Vaccines
• MMR Vaccines
• Combination Vaccines
• Pneumococcal Vaccines
• Polio Vaccines
• Varicella Vaccines
• Other Pediatric Vaccines

As well as Revenues and Forecasts to 2012 for the following adult vaccine categories:

• Influenza Vaccines
• Hepatitis Vaccines
• Pneumococcal Vaccines
• Travel, DT and other Adult Vaccines
• Cervical Cancer

This is a rapidly changing marketplace and knowledge of the R&D pipeline is essential to truly understand what is happening in vaccines. Vaccines in development are discussed in this report, including vaccines for the following conditions:

• Enterotoxigenic Escherichia coli
• Parainfluenza Virus Type 3
• Pneumococcal Vaccines
• Respiratory Syncytial Virus
• Cancers
• Cholera
• HIV/AIDS
• Helicobacter Pylori
• Malaria
• Rabies
• Tuberculosis
• West Nile Virus

This Kalorama Information report was created with a primary research effort - interviews with market experts in the vaccine market who shared insights, informed of new trends and helped to construct models, supplemented by secondary research in company, medical and trade literature. Marketing and Business Development executives, strategic planners, research and development executives, as well as investors and financial consultants are among those who will find this a useful resource.

Table of Contents

CHAPTER ONE: EXECUTIVE SUMMARY

• The Global Vaccine Industry
  • Scope And Methodology
  • Overview
  • Pediatric Preventative Vaccines
• The Market
  • Adult Preventative Vaccines
• The Market
• Total Vaccine Market
• Issues and Trends
• A "Gardasil Effect" in R&D?

CHAPTER TWO: INTRODUCTION TO VACCINES

• A Brief History: The Development of Vaccines
• The Immune Response
• Mechanism of Action
• Types of Vaccines
  • Attenuated (Weakened) Live Viruses
  • Killed (Inactivated) Viruses
  • Toxoid Vaccines
  • Genetically Engineered/Modified Vaccines
    • Subunit Vaccines
    • Conjugate Vaccines
    • DNA Vaccination
• Vaccine Approval Process

CHAPTER THREE: PEDIATRIC VACCINES

• Introduction
• Childhood Immunization in the United States
  • Childhood Immunization Rates
  • Challenges to the Vaccine Delivery System
  • Recommended Childhood Immunization Schedule
  • State Immunization Recommendations
• Pediatric Vaccine Products
  • BCG Vaccines
  • Diphtheria, Tetanus, Pertussis, Hepatitis B and Polio Vaccines
    • Diphtheria
    • Pertussis
    • Tetanus
    • Hepatitis B
    • Poliomyelitis
  • Haemophilus Influenzae Type B Vaccines
  • Hepatitis A Vaccines
  • Measles, Mumps and Rubella Vaccines
    • Measles
    • Mumps
    • Rubella
  • Pneumococcal Conjugate Vaccine
  • Rotavirus Vaccines
  • Varicella Vaccines
  • Meningococcal Vaccines
• Cost of Vaccines in the United States
• Pediatric Vaccines in Development
  • Global Initiatives for Vaccine Research
    • Enterotoxigenic Escherichia coli
    • Parainfluenza Virus Type 3
    • Pneumococcal Vaccines
    • Respiratory Syncytial Virus
• The World Market for Pediatric Preventive Vaccines
  • Total Market Size and Forecast
  • DTP and DTaP Vaccine Market
    • Market Analysis
    • Leading Products and Competitors
  • Hepatitis Vaccine Market
    • Market Analysis
    • Leading Products and Competitors
  • Haemophilus Influenzae Type B Vaccine Market
    • Market Analysis
    • Leading Products and Competitors
  • Measles, Mumps and Rubella Vaccines
    • Market Analysis
  • Combination Vaccines Market
    • Market Analysis
    • Leading Products and Competitors
  • Pneumococcal Vaccine
    • Leading Products and Competitors
  • Poliovirus Vaccine
    • Market Analysis
    • Leading Products and Competitors
  • Varicella Vaccines
    • Market Analysis
    • Leading Products and Competitors
  • Other Vaccines Market
    • Market Analysis
    • Leading Products and Competitors

CHAPTER FOUR: ADULT PREVENTIVE VACCINES

• Introduction
• Adult Vaccine-Preventable Diseases: Facts and Figures
• Global Virological Surveillance Program
• Recommendations for Adult Immunizations
  • WHO International Health Regulations
• Adult Vaccine Products
  • BCG Vaccines
  • Cervical Cancer Vaccines
  • Cholera Vaccines
  • Diphtheria-Tetanus Vaccines
  • Hepatitis Vaccines
    • Hepatitis A
    • Hepatitis B
  • Influenza Vaccines
  • Japanese Encephalitis Vaccines
  • Pneumococcal Disease Vaccines
  • Rabies Vaccines
  • Shingles Vaccine
  • Typhoid Vaccines
  • Yellow Fever Vaccines
• Adult Vaccines in Development
• Global Initiatives for Vaccine Research
  • Cancer
  • Cholera
  • HIV/AIDS
  • Helicobacter Pylori
  • Hepatitis
    • Hepatitis B
    • Hepatitis C
    • Hepatitis E
  • Herpesvirus
  • Influenza
  • Leishmaniasis
  • Malaria
  • Rabies
  • Tuberculosis
  • Typhoid Fever
  • West Nile Virus
• The World Market for Adult Preventive Vaccines
  • Total Market Size and Forecast
  • Cervical Cancer Market
    • Market Analysis
    • Leading Products and Competitors
  • Hepatitis Market
    • Market Analysis
    • Leading Products and Competitors
  • Influenza Vaccine Market
    • Market Analysis
    • Leading Products and Competitors
    • Market Analysis
    • Leading Products and Competitors
  • Travel, DT, and Miscellaneous Vaccine Market
    • Market Analysis
    • Leading Products and Competitors

CHAPTER FIVE: VACCINES MARKET SUMMARY

• Trends Driving the Vaccines Market
• Market Size and Forecast
  • Vaccine Market Competitors
  • Pediatric Vaccines
    • Major Manufacturer' s Market Share
  • Adult Vaccines
    • Major Manufacturer' s Market Share

CHAPTER SIX: ISSUES AND TRENDS

• Resistance to Immunization
• Vaccine Safety
  • Vaccine Adverse Event Reporting System
  • The Vaccine Safety Datalink Project
  • The Vaccine Injury Compensation Program
• Increased US Vaccine Availability
• Vaccine Shortages
  • Preventing Shortages in the Developed Countries
• A ' Gardasil Effect' in R&D?
• Vaccines and Bioterrorism
  • Overview
  • Project Bioshield Act of 2004
  • National Bio and Agro-Defense Facility
  • Vaccine Treatment and Evaluation Units
  • Anthrax
  • Smallpox
  • Plague
  • Botulism
  • Tularemia
  • Viral Hemorrhagic Fevers
• DNA Vaccination
• Innovations in Vaccine Delivery Systems
  • Edible Vaccines
  • Mucosal Delivery
  • Intranasal Delivery
  • Oral Vaccines
  • Vaccine Patches

CHAPTER SEVEN: COMPANY PROFILES

• Acambis plc
  • History and Lines of Business
  • Strategic Alliances
  • Vaccine Products
  • Financial Information
• AlphaVax, Inc.
  • History and Lines of Business
  • Strategic Alliances
  • Vaccine Products
• Avant Immunotherapeutics
  • History and Lines of Business
  • Strategic Alliances
  • Vaccine Products
  • Financial Information
• Bavarian Nordic A/S
  • History and Lines of Business
  • Strategic Alliances
  • Vaccine Products
  • Financial Information
• Baxter Healthcare
  • History and Lines of Business
  • Strategic Alliances
  • Vaccine Products
  • Financial Information
• Crucell
  • History and Lines of Business
  • Strategic Alliances
  • Vaccine Products
  • Financial Information
• Emergent biosolutions
  • History and Lines of Business
  • Strategic Acquisition and Alliance
  • Vaccine Products
  • Financial
• GlaxoSmithKline
  • History and Lines of Business
  • Strategic Alliances
  • Vaccine Products
  • Financial Information
• Medimmune
  • History and Lines of Business
  • Strategic Alliances
  • Vaccine Products
  • Financial Information
• Merck & Co. Inc
  • History and Lines of Business
  • Strategic Alliances
  • Vaccine Products
  • Financial Information
• Nabi Biopharmaceuticals
  • History and Lines of Business
  • Strategic Alliance
  • Vaccine Products
  • Financial Information
• Novartis
  • History and Lines of Business
  • Strategic Alliances
  • Vaccine Products
• Pfizer
  • History and Lines of Business
  • Strategic alliances
  • Vaccine products
  • Financial Information
• Pharmexa
  • History and Lines of Business
  • Strategic alliances
  • Vaccine Products
  • Financial Information
• Sanofi Pasteur
  • History and Lines of Business
  • Strategic Alliances
  • Vaccine Products
  • Financial Information
• Wyeth
  • History and Lines of Business
  • Vaccine Products
  • Financial Information

APPENDIX: COMPANY DIRECTORY

TABLE OF EXHIBITS

CHAPTER ONE: EXECUTIVE SUMMARY

• Figure 1-1: World Market for Pediatric Vaccines 2004-2013 Revenues
• Figure 1-2: World Market for Adult Vaccines 2004-2013 Revenues

CHAPTER TWO: INTRODUCTION TO VACCINES

• Table 2-1: Impact of Vaccines in the 20th Century Annual Morbidity in the 20th Century vs 2006
• Table 2-2: Vaccine-Preventable Diseases, April 2008

CHAPTER THREE: PEDIATRIC PREVENTIVE VACCINES

• Table 3-1: Global Immunization Rates by Vaccine Type 2006
• Table 3-2: Immunization Profile of the United States: Population by Age Group, Number of Vaccine-Preventable Diseases Reported by Disease 2000-2006
• Table 3-3: U.S. Recommended Childhood Immunization Schedule, 2008
• Table 3-4: U.S. Recommended Adolescent Immunization Schedule, 2008
• Table 3-5: Selected Pediatric Vaccines in Development, April 2008
• Table 3-6: World Market for Pediatric Vaccines by Type (DTaP/DTP, Hep, HiB, MMR, Combos, Pneumococcal, Polio, Varicella, Others) 2004-2013
• Figure 3-1: Market Share of Pediatric Vaccines by Type 2007
• Figure 3-2: Market Share of Pediatric Vaccines, by Type 2013
• Table 3-7: World DTP and DTaP Vaccine Market 2004-2013
• Table 3-8: World Pediatric Hepatitis Vaccine Market 2004-2013
• Table 3-9: World Hib Vaccine Market, 2004-2013
• Table 3-10: World MMR Vaccines Market 2004-2013
• Table 3-11: World Combination Vaccines Market 2004-2013
• Table 3-12: World Pediatric Pneumococcal Vaccine Market 2004-2013
• Table 3-13: World Poliovirus Vaccine Market 2004-2013
• Table 3-14: World Varicella Vaccine Market 2004-2013
• Table 3-15: Other Vaccines Market 2004-2013

CHAPTER FOUR: ADULT PREVENTIVE VACCINES

• Table 4-1: Universal Adult Immunization Schedule 2008
• Table 4-2: Adult Immunization Schedule for Populations with Special Medical Conditions, 2008
• Table 4-3: Initiatives to Require HPV Vaccination by U.S. State, 2008
• Table 4-4: Selected Adult Preventive Vaccines in Development, 2008
• Table 4-5: World Market for Adult Preventive Vaccines by Type (Hepatitis, Influenza, Pneumococcal, Travel/DT/Misc.), 2004-2013
• Figure 4-1: Market Share of Adult Vaccines, by Type, 2007 (Cervical Cancer, Hepatitis, Influenza, Pneumococcal, Travel)
• Figure 4-2: Market Share of Adult Vaccines, by Type, 2013
• Table 4-6: World Cervical CancerVaccine Market 2004-2013
• Table 4-7: World Hepatitis Vaccine Market 2004-2014
• Table 4-8: World Influenza Vaccine Market 2004-2013
• Table 4-9: CDC Goal to Double Flu Immunization by 2010 Group and Estimated Immunization Rate (2000 vs 2010)
• Table 4-10: 2007 Estimated Population by Region and Selected Age Group
• Table 4-11: World Pneumococcal Vaccine Market 2004-2013
• Table 4-12: World Travel; Diphtheria-Tetanus; Miscellaneous Vaccines Market 2004-2013

CHAPTER FIVE: VACCINES MARKET SUMMARY

• Table 5-1: The World Vaccines Market by Vaccine Type 2004-2013
• Figure 5-1: World Market for Vaccines by Type 2004-2013
• Figure 5-2: World Market for Vaccines Share by Type, 2004, 2007 and 2013
• Table 5-2: Major Manufacturers' Shares of the World Vaccine Market, 2007 154 Figure 5-3: 2007 World Vaccines Market Share, by Leading Competitors 155 Table 5-3: Major Manufacturer' s Shares of the World Pediatric Vaccine Market 2007
• Figure 5-5: Market Share of Pediatric Vaccines Market, 2007 157 Table 5-4: Major Manufacturer' s Shares of the World Adult Vaccine Market 2007
• Figure 5-6: Market Share of Adult Vaccines Market 2007

CHAPTER SIX: ISSUES AND TRENDS

• Table 6-1: Selected Companies/Laboratories Developing Biodefense Vaccines