世界の整形外科用バイオマテリアル市場における新興動向、技術および機会

Abstract

This report is a detailed assessment of products and technologies in orthopedic biomaterials under development and on the market, including bone grafts (including allografts), bone graft substitutes, polymers, growth factors, surgical glues and sealants, anti-adhesive products, and tissue engineering products. The report addresses the major pathologies requiring surgical intervention (e.g., trauma, degenerative diseases of hip, knee and spine, etc); the most common and most important surgical procedures, with caseload detailed globally and regionally; the range of products available and their role in the various surgical procedures; trends in surgical practice, especially as they affect product uptake; description of the range of product types and specific products in current use; discussion of product trends, including changing market expectations leading research towards new products; and discussion of the main factors driving the market, and those inhibiting growth; the regulatory environment and its evolution; market size and growth, globally and regionally (USA, Europe, Japan, RoW) for 2006; market breakdown by main product types; leading companies and their market shares; five-year market forecasts (2007-11); and company profiles of the largest and/or most important companies.

Table of Contents

• EXECUTIVE SUMMARY
• Definitions
• Materials and Their Uses
  • Bone
  • Polymers
  • Ceramics
  • Other Orthopaedic Biomaterials
  • Growth Factors
  • Surgical Sealants and Glues
  • Anti-Adhesion Products
  • Tissue Engineering
• The Market
  • Total Orthopaedic Market
  • Orthopaedic Biomaterials
  • Industry

Section 1: INTRODUCTION TO ORTHOPEDIC SURGERY AND BIOMATERIALS

• 1.1 Definitions
  • 1.1.1 Bone
  • 1.1.2 Bone Formation
• 1.2 Orthopedic Surgery
  • 1.2.1 Hip Replacement
    • 1.2.1.1 Procedures and Biomaterials
    • 1.2.1.2 Caseload
• 1.3 Knee Replacement and Repair
  • 1.3.1 Knee Replacement: Technique and Biomaterials
    • 1.3.1.1 Anterior Cruciate Ligament (ACL) Repair
    • 1.3.1.2 Caseload
  • 1.3.2 Spinal Surgery
    • 1.3.2.1 Surgical Procedures and Biomaterials
    • 1.3.2.2 Caseload
  • 1.3.3 Fractures
• 1.4 Orthopedic Biomaterials
  • 1.4.1 Graft Materials
    • 1.4.1.1 Bone Allografts
    • 1.4.1.2 Cartilage Allografts
    • 1.4.1.3 Tendon Allografts
    • 1.4.1.4 Safety Concerns with Allografts
  • 1.4.2 Polymers
    • 1.4.2.1 Polymers Used as Biomaterials
    • 1.4.2.2 Bioresorbable Polymers
  • 1.4.3 Ceramics
    • 1.4.3.1 Ceramic Bone Implants
    • 1.4.3.2 Ceramic-on-Ceramic Implants
    • 1.4.3.3 Ceramic Dental Implants
  • 1.4.4 Surgical Glues and Sealants
    • 1.4.4.1 Types of Surgical Sealants
  • 1.4.5 Anti-Adhesives
    • 1.4.5.1 Research in Anti-Adhesives
  • 1.4.6 Tissue Engineering
    • 1.4.6.1 Comparison with Other Therapies
    • 1.4.6.2 Current Research in Tissue Engineering
  • 1.4.7 Growth Factors

Section 2: PRODUCT AND TECHNOLOGY OFFERINGS

• 2.1 Advances in Bone Graft Materials
  • 2.1.1 Selected Product Offerings
    • 2.1.1.1 Allosource
    • 2.1.1.2 AltivaCorp
    • 2.1.1.3 Cortek
    • 2.1.1.4 LifeNet
    • 2.1.1.5 Osteotech Inc.
    • 2.1.1.6 Tutogen Medical
• 2.2 Synthetic Bone Substitutes
  • 2.2.1 Selected Product Offerings
    • 2.2.1.1 Biocoral Inc.
    • 2.2.1.2 CeraPedics
    • 2.2.1.3 CryoLife
    • 2.2.1.4 ETEX Corp.
    • 2.2.1.5 Medtronic Sofamor Danek
    • 2.2.1.6 Novabone LLC
    • 2.2.1.7 OsteoBiologics Inc.
• 2.3 Polymer-based Biomaterials
  • 2.3.1 Selected Product Offerings
    • 2.3.1.1 Arthrex Inc.
    • 2.3.1.2 Arthrotek Inc.
    • 2.3.1.3 Biocoat Inc.
    • 2.3.1.4 Durect Corp.
    • 2.3.1.5 Invibio Material Solutions
    • 2.3.1.6 Protein Polymer Technologies Inc (PPTI)
    • 2.3.1.7 Smith & Nephew plc
    • 2.3.1.8 Zimmer Holdings
• 2.4 Ceramics
  • 2.4.1 Selected Product Offerings
    • 2.4.1.1 Amedica Corp.
    • 2.4.1.2 Angstrom Medica Inc
    • 2.4.1.3 ApaTech Ltd
    • 2.4.1.4 Berkeley Advanced Biomaterials
    • 2.4.1.5 CeramTec AG
    • 2.4.1.6 Encore Medical
    • 2.4.1.7 Interpore Cross International Inc.
    • 2.4.1.8 Japan Medical Materials Company
    • 2.4.1.9 Metoxit AG
    • 2.4.1.10 Morgan Technical Ceramics
    • 2.4.1.11 NovaBone Products LLC
    • 2.4.1.12 OrthoVita Inc
    • 2.4.1.13 OsteoBiologics Inc
    • 2.4.1.14 Stryker
    • 2.4.1.15 Teknimed SA
    • 2.4.1.16 Wright Medical Technology
• 2.5 Growth Factors
  • 2.5.1 Selected Product Offerings
    • 2.5.1.1 Acologix
    • 2.5.1.2 BioMimetic Therapeutics
    • 2.5.1.3 BD Biosciences
    • 2.5.1.4 Biodesign International
    • 2.5.1.5 OrthoLogic
    • 2.5.1.6 Stryker
• 2.6 Tissue Engineering
  • 2.6.1 Selected Product Offerings
    • 2.6.1.1 Aastrom Biosciences Inc.
    • 2.6.1.2 Encelle Inc.
    • 2.6.1.3 Integra Life Sciences
    • 2.6.1.4 Isto Technologies Inc.
    • 2.6.1.5 Ortec International Inc.
    • 2.6.1.6 Osiris Therapeutics Inc.
    • 2.6.1.7 TEI Biosciences Inc.
• 2.7 Sealants and Glues
  • 2.7.1 Selected Product Offerings
    • 2.7.1.1 Abbott Laboratories
    • 2.7.1.2 Closure Medical
    • 2.7.1.3 Angiotech Pharmaceuticals
    • 2.7.1.4 Baxter
    • 2.7.1.5 Confluent Surgical Inc.
    • 2.7.1.6 Haemacure Corp.
    • 2.7.1.7 Cryolife
    • 2.7.1.8 Nycomed
    • 2.7.1.9 ThermoGenesis Corp.
    • 2.7.1.10 Tissuemed Ltd.
• 2.8 Anti-Adhesion Products
  • 2.8.1 Selected Product Offerings
    • 2.8.1.1 Angiotech Pharmaceuticals
    • 2.8.1.2 Confluent Surgical
    • 2.8.1.3 Genzyme Inc.
    • 2.8.1.4 Johnson & Johnson Inc.
    • 2.8.1.5 Tissuemed
• 2.9 Orthopedic Surgical Trends

Section 3: THE ORTHOPEDIC BIOMATERIALS MARKET: SIZE, GROWTH, PARTICIPANTS AND TRENDS

• 3.1 Market Size
• 3.2 The Market for Orthopaedic Biomaterials
• 3.3 Regional Markets
  • 3.3.1 North America
  • 3.3.2 Western Europe
  • 3.3.3 Japan
• 3.4 Markets by Materials
  • 3.4.1 Allografts
    • 3.4.1.1 Companies and Products
  • 3.4.2 Synthetic Bone Substitutes
  • 3.4.3 Polymers
    • 3.4.3.1 Companies and Products
  • 3.4.4 Ceramics
    • 3.4.4.1 Companies and Products
  • 3.4.5 Growth Factors
    • 3.4.5.1 Companies and Products
  • 3.4.6 Tissue Engineering
  • 3.4.7 Sealants and Glues
    • 3.4.7.1 Companies and Products
  • 3.4.8 Anti-Adhesion Products
    • 3.4.8.1 Companies and Products
  • 3.4.9 Other - Viscosupplementation
    • 3.4.9.1 Market
    • 3.4.9.2 Companies and Products
• 3.5 Market Analysis by Clinical Use
  • 3.5.1 Hip and Knee Surgery
  • 3.5.2 Spinal Surgery
  • 3.5.3 Trauma
• 3.6 Leading Companies

Section 4: Company profiles

• 4.1 Aastrom Biosciences, Inc.
  • 4.1.1 Products
  • 4.1.2 Financials
• 4.2 Absorbable Polymer International
• 4.3 Acologix Inc.
  • 4.3.1 Products
  • 4.3.2 Financials
• 4.4 Advanced Cell Technology Inc.
  • 4.4.1 Financials
• 4.5 Allograft Tissue Systems Inc (ATSI)
  • 4.5.1 Products
• 4.6 Allosource
• 4.7 Alphatec Spine, Inc.
  • 4.7.1 Products
• 4.8 Altiva Corporation
  • 4.8.1 Products
• 4.9 Amedica Corporation
  • 4.9.1 Products
  • 4.9.2 Financials
• 4.10 Angstrom Medica Inc.
  • 4.10.1 Product
  • 4.10.2 Financials
• 4.11 ApaTech Ltd.
  • 4.11.1 Product
• 4.12 Arthrex
• 4.13 Arthrotek
  • 4.13.1 Products
• 4.14 Artimplant
  • 4.14.1 Products
    • 4.14.1.1 Artelon Bone Scaffold
    • 4.14.1.2 Artelon Membrane
    • 4.14.1.3 Artelon TMC Spacer
    • 4.14.1.4 SportMesh
  • 4.14.2 Financials
• 4.15 Berkeley Advanced Biomaterials Inc.
  • 4.15.1 Products
    • 4.15.1.1 Bi-Ostetic
    • 4.15.1.2 Cem-Ostetic
    • 4.15.1.3 GenerOs
    • 4.15.1.4 Demineralized Bone Matrix
• 4.16 Biocoat Inc.
  • 4.16.1 Product: Hyaluronan
• 4.17 Biocomposites Ltd
  • 4.17.1 Prducts
    • 4.17.1.1 Bilok
    • 4.17.1.2 Biosteon
    • 4.17.1.3 Genex
    • 4.17.1.4 Allogran-R
    • 4.17.1.5 Stimulan
• 4.18 Biocoral, Inc.
  • 4.18.1 Product: Biocoral
• 4.19 BioMimetic Therapeutics Inc.
  • 4.19.1 Products
  • 4.19.2 Financials
• 4.20 Biopharm GmbH
  • 4.20.1 Product: rhGDF-5/MP52
• 4.21 BioSyntech Inc.
  • 4.21.1 Products
• 4.22 CeramTec AG
  • 4.22.1 Products
    • 4.22.1.1 Hip Joint Components
    • 4.22.1.2 Knee Joint Components
• 4.23 CeraPedics LLC
  • 4.23.1 Products
• 4.24 Clearant Inc.
• 4.25 Closure Medical Corporation
• 4.26 Cortek, Inc.
• 4.27 Cryolife, Inc.
  • 4.27.1 Products
    • 4.27.1.1 BioGlue
    • 4.27.1.2 BioDisc
  • 4.27.2 Financials
• 4.28 De Puy Inc.
  • 4.28.1 Products
    • 4.28.1.1 α-BSM Bone Substitute Material
    • 4.28.1.2 Conduit TCP Granules
    • 4.28.1.3 Cellect
    • 4.28.1.4 Symphony II PCS
    • 4.28.1.5 I/C Graft Chamber
    • 4.28.1.6 Charité Artificial Disc
  • 4.28.2 Financials
• 4.29 Encelle Inc.
  • 4.29.1 Product: E-Matrix
  • 4.29.2 Financials
• 4.30 Encore Medical
  • 4.30.1 Products
    • 4.30.1.1 Keramos
    • 4.30.1.2 3DMatrix porous coating
  • 4.30.2 Financials
• 4.31 Enobia Pharma Inc.
  • 4.31.1 Financials
• 4.32 Etex Corporation.
  • 4.32.1 Product: α-BSM
• 4.33 Fidia Advanced Biopolymers s.r.l.
  • 4.33.1 Products
    • 4.33.1.1 HYAFF
    • 4.33.1.2 TissueTech
• 4.34 FzioMed Inc.
  • 4.34.1 Product: Oxiplex
• 4.35 Genzyme Biosurgery, Inc.
  • 4.35.1 Products
  • 4.35.2 Financials
• 4.36 Haemacure Corporation
• 4.37 Inion Ltd
  • 4.37.1 Products
• 4.38 Integra Lifesciences Holdings Corporation
  • 4.38.1 Products
    • 4.38.1.1 Duraplasty Products
    • 4.38.1.2 Adhesion Barrier for the Spine
  • 4.38.2 Financials
• 4.39 Interpore Cross International
  • 4.39.1 Products
• 4.40 Invibio Material Solutions
  • 4.40.1 Products
• 4.41 Isotis, N.V.
  • 4.41.1 Products
    • 4.41.1.1 Accell
    • 4.41.1.2 Other Products
  • 4.41.2 Financials
• 4.42 Isto Technologies Inc.
  • 4.42.1 Products
  • 4.42.2 Financials
• 4.43 Japan Medical Materials Corporation
  • 4.43.1 Products
• 4.44 LifeCell Corp.
  • 4.44.1 Product: AlloDerm
  • 4.44.2 Financials
• 4.45 LifeNet Allografts
  • 4.45.1 Products
• 4.46 Medtronic Sofamor Danek
  • 4.46.1 Products
    • 4.46.1.1 Prestige LP Cervical Disc
    • 4.46.1.2 Infuse Bone Graft
    • 4.46.1.3 Minimal Access Spinal Surgery
  • 4.46.2 Financials
• 4.47 Metoxit AG
  • 4.47.1 Products
• 4.48 Morgan Advanced Ceramics
  • 4.48.1 Products
  • 4.48.2 Financials
• 4.49 NovaBone Products LLC
  • 4.49.1 Products
    • 4.49.1.1 PerioGlas
    • 4.49.1.2 NovaBone-C/M
    • 4.49.1.3 NovaBone
• 4.50 Ortec International, Inc.
  • 4.50.1 Products
    • 4.50.1.1 Orcel
    • 4.50.1.2 Other Product Candidates
• 4.51 OrthoLogic Corporation
  • 4.51.1 Products
  • 4.51.2 Financials
• 4.52 Orthovita, Inc.
  • 4.52.1 Products
    • 4.52.1.1 Vitoss
    • 4.52.1.2 Cortoss
    • 4.52.1.3 Rhakoss
  • 4.52.2 Financials
• 4.53 Osiris Therapeutics Inc.
  • 4.53.1 Products
    • 4.53.1.1 Osteocel
    • 4.53.1.2 Prochymal
    • 4.53.1.3 Provacel
    • 4.53.1.4 Chondrogen
  • 4.53.2 Financials
• 4.54 OsteoBiologics Inc
  • 4.54.1 Products
• 4.55 Osteohealth Company
  • 4.55.1 Products
    • 4.55.1.1 Bio-Oss
    • 4.55.1.2 Bio-Gide
    • 4.55.1.3 Bio-Oss Collagen
    • 4.55.1.4 Gem 21S
• 4.56 Osteotech, Inc.
  • 4.56.1 Products
  • 4.56.2 Financials
• 4.57 Protein Polymer Technologies Inc.
  • 4.57.1 Spinal Product: Injectable Disc Nucleus
• 4.58 Regen Biologics, Inc.
• 4.59 Regeneration Technologies, Inc.
  • 4.59.1 Products
    • 4.59.1.1 BioCleanse
    • 4.59.1.2 Sterling Biological Matrix
• 4.60 Smith & Nephew, plc.
  • 4.60.1 Products
    • 4.60.1.1 Exogen
    • 4.60.1.2 Supartz
  • 4.60.2 Financials
• 4.61 Stryker Biotech
  • 4.61.1 Products
    • 4.61.1.1 OP-1
    • 4.61.1.2 TissueMend
    • 4.61.1.3 HydroSet
    • 4.61.1.4 BoneSource
    • 4.61.1.5 BoneSave
  • 4.61.2 Financials
• 4.62 Synthes, Inc.
  • 4.62.1 Products
    • 4.62.1.1 Norian SRS
    • 4.62.1.2 chronOS
    • 4.62.1.3 PolyMax
    • 4.62.1.4 Norian Craniofacial Repair System
  • 4.62.2 Financials
• 4.63 TEI Biosciences
  • 4.63.1 Products
    • 4.63.1.1 SurgiMend
    • 4.63.1.2 PriMatrix
    • 4.63.1.3 Durepair
    • 4.63.1.4 TissueMend
    • 4.63.1.5 Xenform
• 4.64 Teknimed SA
  • 4.64.1 Products
    • 4.64.1.1 Hydroxyapatite
    • 4.64.1.2 Cementek
    • 4.64.1.3 TRIHA +
    • 4.64.1.4 Ceraform
• 4.65 Tutogen Medical, Inc.
  • 4.65.1 Financials
• 4.66 Wright Medical Technology, Inc.
  • 4.66.1 Products
    • 4.66.1.1 Osteogenic Grafting Solutions
    • 4.66.1.2 Synthetic Grafting Solutions
    • 4.66.1.3 Advanced Membrane Technology
  • 4.66.2 Financials

APPENDIX

Company Contact Details

List of Exhibits

• Exhibit ES-1: Examples of Polymers Used in Orthopaedics
• Exhibit ES-2: Worldwide Market for Orthopaedic Devices
• Exhibit ES-3: Size and Growth of Worldwide Orthopaedic Biomaterials Market, 2006-2011
• Exhibit ES-4: Orthopaedic Biomaterials Market by Region, 2006
• Exhibit ES-5: Company Shares of the U.S. Orthopaedic Biomaterials Market, 2005
• Exhibit 2-1: Allograft Products
• Exhibit 2-2: Synthetic Bone Products
• Exhibit 2-3: Polymer-Based Products
• Exhibit 2-4: Ceramic-Based Products
• Exhibit 2-5: Growth Factor Products
• Exhibit 2-6: Tissue Engineering Products
• Exhibit 2-7: Sealants and Haemostat Products
• Exhibit 2-8: Anti-Adhesion Products
• Exhibit 3-1: Current Value and Growth of Orthopaedic Device Market
• Exhibit 3-2: Countries Having at Least 10% of Their Population Age 65 and Over, by Population Totals and Percentages, 2003
• Exhibit 3-3: Size and Growth of Worldwide Orthopaedic Biomaterials Market, 2006-2011
• Exhibit 3-4: Main Product Groups in US Orthopaedic Biomaterials Market, 2005
• Exhibit 3-5: European Orthopaedics Market, 2005
• Exhibit 3-6: Orthopaedic Biomaterials Market by Region, 2006
• Exhibit 3-7: Allograft Market in 2006 and 2011
• Exhibit 3-8: Regional Distribution of World Allograft Market, 2006
• Exhibit 3-9: Worldwide Market for Synthetic Bone Substitutes, 2006-2011
• Exhibit 3-10: Polymers in Orthopaedic Biomaterials: Market Value and Growth
• Exhibit 3-11: Regional Distribution of World Market for Orthopaedic Polymers, 2006
• Exhibit 3-12: Worldwide Market for Ceramic Biomaterials, 2006-2011
• Exhibit 3-13: Regional Distribution of World Market for Orthopaedic Ceramics, 2006
• Exhibit 3-14: Worldwide Market for Bone Growth Factors, 2006-2011
• Exhibit 3-15: Regional Distribution of World Market for Orthopaedic Bone Growth Factors, 2006
• Exhibit 3-16: Worldwide Market for Surgical Sealants, Glues and Haemostats
• Exhibit 3-17: Regional Distribution of World Market for Sealants, Glues and Haemostats in Orthopaedics, 2006
• Exhibit 3-18: Worldwide Market for Anti-Adhesive Products
• Exhibit 3-19: Regional Distribution of World Anti-Adhesion Products Market, 2006
• Exhibit 3-20: World Orthopaedic Biomaterials Market, 2006-2011, By Product Categories
• Exhibit 3-21: World and Regional Viscosupplementation Markets, 2006
• Exhibit 3-22: Sales of Leading Hyaluronic Acid Products, 2005
• Exhibit 3-23: Orthopaedic Market by Clinical Use and Device Type, 2006
• Exhibit 3-24: Hip and Knee replacements, USA
• Exhibit 3-25: Company Shares in the Main Regional Orthopaedic Biomaterials Markets, 2005
• Exhibit 4-1: Aastrom Financial Data, Year to June 30th 2006
• Exhibit 4-2: Advanced Cell Technology Financial Data for Six months to June 30, 2006
• Exhibit 4-3: Artimplant Selected Financial Data, 2004-2005
• Exhibit 4-4: BioMimetic Selected Financial Data for Six Months to June 30 2006 and 2005
• Exhibit 4-5: CryoLife Selected Financial Data, 2005
• Exhibit 4-6: Encore Medical Selected Financial Data, 2004-2005
• Exhibit 4-7: Integra Lifesciences Selected Financial Data, 2004-2005
• Exhibit 4-8: IsoTis Selected Financial Data, 2004-2005
• Exhibit 4-9: LifeCell Selected Financial Data, 2005
• Exhibit 4-10: Medtronic Selected Financial Data for Years to April 30th 2006 and 2005
• Exhibit 4-11: The Morgan Crucible Company Selected Financial Data for The Morgan Crucible Company, 2005
• Exhibit 4-12: OrthoLogic Selected Financial Data, 2003-2005
• Exhibit 4-13: OrthoVita Selected Financial Data, 2004-2005
• Exhibit 4-14: Osiris Therapeutics Selected Financial Data, Six Months to June 30th, 2006
• Exhibit 4-15: Osteotech Selected Financial Data, 2003-2005
• Exhibit 4-16: Smith & Nephew, Selected Financial Data, 2004-2005
• Exhibit 4-17: Stryker Selected Financial Data for 9 months to September 30th 2006 and 2005
• Exhibit 4-18: Synthes Selected Dinancial Data, 2004-2005
• Exhibit 4-19: Wright Medical Group Selected Financial Data for the first 9 months of 2006 and 2005