バイオテクノロジーにおける上流・下流の処理技術：北米・アジア・欧州市場

Abstract

This Frost & Sullivan research service titled Biotechnology: UpStream and DownStream Processing Technology Analysis examines the developments in bioprocessing and enabling technologies such as transgenic production of proteins in plants, microorganisms, mammalian cells, and eggs. It also includes an in-depth analysis of new separation technologies for downstream processing and technologies for genetically engineering more potent antibodies and enzymes with higher activity, among others.

Table of Contents

1 EXECUTIVE SUMMARY

• Introduction
  • Introduction
  • Technology Primer
• Scope and Methodology
  • Scope
  • Methodology

2 TECHNOLOGY AND APPLICATIONS VIEWPOINT

• Application Analysis and Trends
  • Microbial Fermentation
  • Glycomics and Biopharmaceuticals
  • Diagnostic Applications
  • Therapeutic Applications
  • Biopolymers
  • Cell Culture
  • Sensors in Biotechnology Processing
  • Other Applications
• Industry Trends and Assessment
  • Industry Trends
  • Mergers and Acquisitions
  • Regulatory Issues
  • Funding Analysis

3 ASSESSMENT OF INNOVATIONS IN UPSTREAM PROCESSING: NORTH AMERICA ASIA AND EUROPE

• Antibodies
  • Enhanced Genetic Evolution--USA
  • Phage Display and Humanized Antibodies--USA
  • RNA Synthesis and Delivery of Antibodies--USA
  • Humanized Antibodies from Yeast--USA
  • Comparing Polyclonal Humanized Antibodies with Monoclonals--USA
  • High-Throughput High-Diversity Generation of Antibody Platform--UK
  • Fucose Increases Antibody-Dependent Cellular Cytotoxicity--Japan
  • Production of Fully Human Antibodies through Human Combinatorial Antibody Libraries--Germany
  • Phage Display Technique Targets Bacterial Haptens--UK
  • Other Companies
• Vaccines
  • Flu Vaccine from Cell Culture Instead of Eggs--USA
  • Potato Vaccine for Hepatitis B--USA
• Antibiotics
  • Antimicrobial Peptide from Fungus Kills Resistant Infections--Denmark
  • Metabolic Pathway Engineering Simplifies Antibiotic Preparation--Netherlands
• Other Biopharmaceuticals
  • Improved Recombinant Interferon--USA
  • Bioconversion for Production of Chiral Compounds--Japan
  • Biocatalysis and Metabolic Engineering for Vitamin and Nutrient Production--Germany
  • Modified E. Coli Make Human Glycoproteins--USA
• Enzymes
  • Fungal Genome Sequence for Better Enzymes--USA
  • Directed Evolution: Increased Mutation Rate Yields Enhanced Enzymes--USA
  • Solid-Phase Massively-Parallel Screening System for Improved Enzyme Mutants--USA
  • Rearranging DNA to Improve Variants--USA
  • Genetic Engineering to Boost Xylanase Output--Canada
• Plants and Algae
  • Lack of Financing Shuts down Large-Scale Biology--USA
  • Transgenic Duckweed for Protein Manufacture--USA
  • Tobacco Plant-Based Monoclonal Antibodies against Tumor Cells--USA
  • Cotton Roots Produce Gossypol Antibiotic--USA
  • Metabolomics Changes Plants to Chemical Factories--USA
  • Insulin Production in Plants--Canada
  • Polysaccharide from Immobilized Callus Cultures--India
• Transgenic Animals
  • Human Antibodies and Other Therapeutic Proteins from Chicken Eggs--USA
  • Transgenic Mice for Production of Fully Human Antibodies--USA
  • Human Antithrombin from Transgenic Goat Milk--USA
  • Transgenic Rabbits Produce C1 Inhibitor for Hereditary Angioedema--Spain
• Biopolymers
  • Stabilized Gene Transfer for Producing Recombinant PHA--USA
  • Yeast Produces Tailor-Made PHA Polymers--USA
  • Limiting Nitrogen Boosts Bacterial PHA Synthesis--Ireland
• Bioreactors and Fermenters
  • Eliminating Cryptic Plasmid Improves Fermentation--USA
  • Microreactor Regenerates Enzyme Cofactors--USA
  • Boost Cobalamin to Improve Fermentation Microbes--USA
  • Novel Two-Phase Fermenter Process--Netherlands
  • Tubular versus Bubble Column Photobioreactors--Spain
• Cell Culture
  • Stable Analog of Poly D-Lysine for Fastidious Cells--USA
  • Nanofiber-Based Cell-Culture Platform--USA
  • Single Cell from Embryo Can Generate Stem Cell Lines--USA
  • Feeder-Free Derivation of Embryonic Stem Cells--USA
  • Artificial Intelligence Controls Cell-Culture Parameters--Finland
  • Special Culture Dish for Both Long-Term Cell Culture and Imaging--Germany
  • Additional Companies
  • Growing Bone Cells on Carbon Nanotubes--USA
  • 3D Capillary Channeled Fibers for Scaffolds--USA
• Sensors and Detectors
  • Universal Detector for HPLC--USA
  • CCD Technology-Based Image Sensors for Process Control--UK
  • Augmenting Cell Culture Optimization Using Optical Sensors--USA
  • Biosensor Dye Aids Viewing Proteins in Live Cells--USA
  • Biocompatible Poly (Dimethylsiloxane) Coatings for Sensors and Microfluidic Devices--USA
  • Fiber-Optic Sensor Measures pH--USA
  • Novel Ultrasonic Sensor for In Situ Detection of Protein Fouling--China

4 ASSESSMENT OF INNOVATIONS IN DOWNSTREAM PROCESSING: NORTH AMERICA ASIA AND EUROPE

• Nucleic Acid Purification
  • RNA Manufacturing In cGMP Facility--USA
  • ChargeSwitch Technology to Purify Nucleic Acids--USA
  • Convoluted Polymer-Coated Beads for High-Yield mRNA Purification--Netherlands
  • Column To Purify Plasmid DNA--Slovenia
• Chromatography
  • High Speed Ultraperformance Liquid Chromatography (UPLC)--USA
  • Removal of Abundant Proteins Allows Purification of Low-Abundance Proteins--USA
  • Liquid-Liquid Counter-Current Chromatography Saves Time and Money--UK
  • Molecularly Imprinted Polymers for Large-Scale Specific Separations--Sweden
  • Additional Companies
• Membrane and Filter Separations
  • Nanofilter Traps Micron-Sized Particles--USA
  • Portfolio of Specialized Filters--USA
  • Membrane Processing Improves Enzyme Production Pharmaceutical Applications--Sweden
  • Multichannel Membranes for Microfiltration--France
  • Additional Companies
• Manufacture and Scale-Up
  • Large-Scale Process for Ricin Vaccine Production--USA
  • True Micro-Bioreactor Scale-Up--USA
  • Step-Wise Scale-Up of Pharma Protein Production Up to 25000 Liters--Netherlands
  • Additional Companies
• Process Design and Management Software
  • Enhancements to Execution Software--USA
  • Software for Enhanced Asset Performance--USA
  • Software Portfolio for Process Manufacturers--USA
  • Computer Modeling Platform Predicts Cellular Metabolism and Behavior--USA

5 TECHNOLOGY ADOPTION FACTOR ANALYSIS

• Technology Development Restraints And Market Challenges
  • Technology Restraints
  • Technology Challenges
  • Competing Technologies
• Technology Adoption Drivers and Benefits
  • Adoption Drivers
  • Technology Benefits

6 DATABASE OF KEY INDUSTRY PARTICIPANTS AND SELECTED PATENTS

• Patents
  • US Patents
  • International Patents
• Key Industry Participants
  • Companies
  • Universities

7 FROST & SULLIVAN 2006 SCIENCE & TECHNOLOGY AWARDS

• Technology Leadership Award
  • Award Description
  • Award Recipient
• Technology Innovation Award
  • Award Description
  • Award Recipient
• Excellence in Technology Award
  • Award Description
  • Award Recipient

8 DECISION SUPPORT DATABASE

• Database Tables
  • Biotech Companies (1999-2006)
  • Biotech Employees (1999-2006)
  • Biotech Private Investment (1999-2006)
  • EPO Biotech Patents (1999-2006)
  • Government Biotech R&D Investment (1999-2006)
  • USPTO Biotech Patents (1999-2006)
  • Percent Government Biotech Investment (1999-2006)