マイクロアレイ市場動向

Abstract

A microarray is an arrangement of miniaturized test sites or "spots" on a surface. Each spot is usually no more than 250 micrometers in diameter and contains biological molecules-usually DNA or protein-which act as probes for a test sample applied to the array. The surface may be a glass slide, a plastic plate with wells or a polymer bead. The microarray format allows many tests or experiments to be performed simultaneously, in parallel, leading to the generation of huge amounts of biological information for the application of only a tiny amount of sample. Microarrays are often also known as "biochips". The purpose of this TriMark Publications report is to describe the specific segment of the microarray market aimed at analysis of proteins and DNA. Protein microarray applications include: 1) expression profiling; 2) serum-based diagnostics; 3) protein-protein binding assays; 4 drug-target binding; and 5) receptor epitope binding. It examines the market for DNA and protein array testing equipment and supplies using screening reagents and instruments for analysis of individual components in blood, serum or plasma. It defines the dollar volume of sales, both worldwide and in the U.S., and analyzes the factors that influence the size and the growth of the market segments. Also examined are the subsections of each market segment, including the research labs, hospital labs, and commercial laboratories. Additionally, the numbers of institutions using this type of testing and the factors that influence purchases are discussed. The report surveys almost all of the companies known to be marketing, manufacturing or developing instruments and reagents for the protein array market in the U.S. Each company is discussed in depth with a section on its history, product line, business and marketing analysis, and a subjective commentary of the company' s market position.

Table of Contents

1. Overview 4

• 1.1 Statement of Report 4
• 1.2 About This Report 4
• 1.3 Scope of the Report 5
• 1.4 Objectives 6
• 1.5 Methodology 6
• 1.6 Executive Summary 7

2. Overview of Microarrays 9

• 2.1 History of Microarrays 9
• 2.2 Genomics and Proteomics 10
• 2.2.1 Genetic Variability and Disease 11
• 2.3 General Theory of Microarrays 11
• 2.4 DNA Microarrays 12
• 2.5 Protein Microarrays 14
• 2.6 Tissue Microarrays 15

3. DNA Microarrays 17

• 3.1 Advantages and Drivers 17
• 3.2 Limitations and Barriers to Commercialization 18
• 3.3 DNA Microarray Technology Platforms 19
  • 3.3.1 Reasons Why Researchers Utilize DNA Microarrays 23
  • 3.3.2 Factors for Difficulties Applying DNA Microarrays Technology 23
• 3.4 Key Attributes of DNA Microarray Software 24
• 3.5 Applications 24
• 3.6 Future Directions for DNA Microarray Technology 29
  • 3.6.1 High-Throughput Array Technology 29
  • 3.6.2 Emerging Microarray Trends 31
  • 3.6.3 Emerging Microarray Applications 31
  • 3.6.4 Key Points for Developing Microarray Based Applications 32

4. Protein Microarrays 33

• 4.1 Critical Factors for Microarray Content 33
• 4.2 Key Findings on Use of Microarrays 33
• 4.3 Advantages and Drivers 34
• 4.4 Limitations and Barriers to Commercialization 36
• 4.5 Key Experimental Parameters of Protein Microarray Technology for Current and Future Users 38
• 4.6 Reasons Why Researchers Utilize Protein Microarrays 39
• 4.7 Factors for Adoption of Protein Microarrays Technology 39
• 4.8 Top Suppliers of Protein Microarray Slides and Products 40
• 4.9 Factors that Influence Sale Decisions 40
• 4.10 Future Innovations in Protein Microarray Technology 40

5. Current DNA Microarrays 41

• 5.1 Key Players 41
• 5.2 High Growth Applications 43
  • 5.2.1 Microarray-Based Commercial Genotyping Activity 43
  • 5.2.2 Location Analysis 43
• 5.3 Future Innovations in DNA Microarray Technology 43

6. Current Protein Microarrays 45

• 6.1 Protein Profiling Microarrays-Antibody Arrays 45
• 6.2 Protein Profiling Microarrays-Reverse Phase Microarrays 47
• 6.3 Multiplex Sandwich Microarrays-Planar 48
• 6.4 Multiplex Sandwich Immunoassays-Bead Based 50
• 6.5 Microarrays for Protein Function Studies 52
• 6.6 High Growth Applications 54
  • 6.6.1 Cytokine Arrays 54
  • 6.6.2 Whole Proteome Arrays 54
  • 6.6.3 Microarray-Based Commercial Genotyping Activity 54
    • 6.6.3.1 Microarray-Based Genotyping Applications 54
    • 6.6.3.2 Microbial Applications 55
    • 6.6.3.3 The Market for Microbial Genotyping Products 56
    • 6.6.3.4 Comparative Genomic Hybridization 56
  • 6.6.4 ChIP-on-Chip Analysis 57

7. Technology 59

• 7.1 Production of Microarrays 59
• 7.2 2-D Versus 3-D Technology 61
• 7.3 Substrates and Surface Chemistries 61
• 7.4 Detection Methods 63
• 7.5 Instruments 63
• 7.6 Data Management and Informatics in Gene Expression 64

8. Applications 65

• 8.1 DNA Microarrays in Gene Expression 65
• 8.2 DNA Microarrays in SNP Analysis 68
• 8.3 DNA Microarrays in Cancer 69
• 8.4 Protein Expression 69
  • 8.4.1 Cytokine Applications 70
  • 8.4.2 Protein Function 70
  • 8.4.3 Protein-Protein Interactions 71
• 8.5 Target /Biomarker Discovery 71
• 8.6 Drug Discovery and Development (Gene and Protein Microarrays) 72
• 8.7 Clinical Diagnostics (Gene and Protein Microarrays) 72
• 8.8 RNA Microarrays 73
• 8.9 Oligo Microarrays 73
• 8.10 Yeast Microarrays 74
• 8.11 Antibody Arrays 74

9. The Commercial Opportunity for Microarrays 75

• 9.1 Market Drivers for Microarrays 75
• 9.2 Market Restraints for Microarrays 75
• 9.3 Key Players 76
• 9.4 Market Size, Strategic Trends and Competitive Landscape for Protein Arrays 79
• 9.5 Marketing and Distribution 81
• 9.6 Protein Arrays Market Analysis 82
• 9.7 Genes Associated with Major Diseases 83
• 9.8 Software and Data Analysis 83
  • 9.8.1 Supplier of DNA Microarray Analysis Software 84
  • 9.8.2 Satisfaction with Software Features 84
  • 9.8.3 Satisfaction with Software 84
  • 9.8.4 Supplier Factors in Software Purchase Decision 84
  • 9.8.5 Suppliers' Role in Improving Data Sharing for DNA Microarrays 84

10. Legal Aspects of Commercialization of Protein Arrays 85

11. Company Profiles 87

Appendix 1: Microarray Milestones 124

LIST OF FIGURES

• Figure 5.1: Company Market Shares 41
• Figure 8.1: Overall Market Size by Application, 2005 66
• Figure 8.2: Source of Variation in Microarray Data 73

LIST OF TABLES

• Table 3.1: Source of DNA Microarrays in Research Use 17
• Table 3.2: Microarray Market Drivers 17
• Table 3.3: Microarray Market Barriers 18
• Table 3.4: Unit Pricing of DNA Microarrays, 2000-2010 18
• Table 3.5: Steps in the Design and Implementation of a DNA Microarray Experiment 20
• Table 3.6: The Main Features of Some Hybridization Microarray Formats Currently Available 21
• Table 3.7: Microarray Applications 24
• Table 3.8: List of DNA Array Manufacturers 26
• Table 4.1: Critical Factors for Microarray Content 33
• Table 4.2: Top Three Suppliers of Treated Protein Microarray Surfaces for Self-Printing 40
• Table 4.3: Top Suppliers of Commercially Available Protein Microarrays 40
• Table 4.4: Top Suppliers of Protein Microarray Readers 40
• Table 5.1: Affymetrix Sales of Probe Arrays, 2000-2005 42
• Table 5.2: Affymetrix Total Product Sales, 1999-2005 42
• Table 5.3: Affymetrix Instrument Sales, 2000-2005 42
• Table 6.1: Microarray Genetic Testing 54
• Table 6.2: ChIP-on-Chip Microarray Market Size Projections, 2005-2011 57
• Table 8.1: Applications of Biochips by Class 65
• Table 8.2: Diagnostics Microarray Market Size Projections, 2005-2011 66
• Table 8.3: HTS Microarray Market Size Projections, 2005-2011 66
• Table 8.4: Pharmacogenomics Microarray Market Size Projections, 2005-2011 67
• Table 8.5: Toxicology Screening Microarray Market Size Projections, 2005-2011 67
• Table 8.6: Expression Profiling Microarray Market Size Projections, 2005-2011 67
• Table 9.1: Market Share of Microarray Products, 2004 76
• Table 9.2: Affymetrix Product Sales 77
• Table 9.3: Agilent' s Net Revenue by Business Segment, 2002, 2003 and 2004 77
• Table 9.4: Leading Microarray Companies 78
• Table 9.5: Worldwide Microarray Market Size, 2004-2011 79
• Table 9.6: Microarray Market Share by Technology Type 79
• Table 9.7: DNA Microarray U.S. Market Size, 2005-2011 80
• Table 9.8: DNA Microarray Worldwide Market Size, 2002-2011 80
• Table 9.9: Biochip Market by Usage, 2003 and 2007 80

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